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| HotDog domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Cartoon representation of the molecular structure of the crystal structure of TT0310 protein from Thermus thermophilus HB8 (PDB: 1WLU) [1] | |||||||||
| Identifiers | |||||||||
| Symbol | HotDog | ||||||||
| Pfam | PF03061 | ||||||||
| Pfam clan | CL0050 | ||||||||
| ECOD | 222.1.1 | ||||||||
| InterPro | IPR029069 | ||||||||
| |||||||||
In molecular biology, the HotDog domain is a protein structural motif found in a diverse superfamily of enzymes, primarily thioesterases and dehydratases. The name "HotDog" refers to its characteristic structure, where a central α-helix (the "sausage") is wrapped by a curved β-sheet (the "bun").[2]
- ^ Kunishima N, Asada Y, Sugahara M, Ishijima J, Nodake Y, Sugahara M, et al. (September 2005). "A novel induced-fit reaction mechanism of asymmetric hot dog thioesterase PAAI". Journal of Molecular Biology. 352 (1): 212–228. doi:10.1016/j.jmb.2005.07.008. PMID 16061252.
- ^ Dillon SC, Bateman A (August 2004). "The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases". BMC Bioinformatics. 5: 109. doi:10.1186/1471-2105-5-109. PMC 516016. PMID 15307895.