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The House of Dampierre played an important role during the Middle Ages. Named after Dampierre, in the Champagne region, where members first became prominent, members of the family were later Count of Flanders, Count of Nevers, Counts and Dukes of Rethel, Count of Artois and Count of Franche-Comté.
Guy II of Dampierre, with his wedding with Mathilde of Bourbon, became also lord of Bourbon and founded the House of Bourbon-Dampierre.
The senior line of the House came to an end with the death of Margaret III in March 1405. She was succeeded in Flanders, Artois, Nevers and Franche-Comté by her eldest son John the Fearless and in Rethel by her younger son Anthony, which marked the start of the House of Valois-Burgundy. The junior line, springing from a younger son of Guy I reigning in Namur, ended in 1429. The earliest known member of the House of Dampierre is Guy I of Dampierre, great-grandson of Guy I of Montlhéry through his son Milo I of Montlhéry.
The members of the House of Dampierre had an antagonistic relation with the House of Avesnes.