HuD (protein)

ELAVL4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FXL, 1G2E
Identifiers
Aliases	ELAVL4, HUD, PNEM, HuD, ELAV like neuron-specific RNA binding protein 4, ELAV like RNA binding protein 4
External IDs	OMIM: 168360; MGI: 107427; HomoloGene: 40729; GeneCards: ELAVL4; OMA:ELAVL4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	50,203,772 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	110,351,909 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ganglionic eminence; ; Brodmann area 23; ; middle temporal gyrus; ; pons; ; Brodmann area 46; ; parietal lobe; ; postcentral gyrus; ; superior frontal gyrus; ; sperm;
	Top expressed in
	habenula; ; ventral tegmental area; ; medial vestibular nucleus; ; superior cervical ganglion; ; trigeminal ganglion; ; ganglionic eminence; ; neural tube; ; pontine nuclei; ; medial ganglionic eminence; ; Rostral migratory stream;
	More reference expression data
	More reference expression data
Orthologs
	1996
	15572
	ENSG00000162374
	ENSMUSG00000028546
	P26378
	Q61701
NM_001144774; NM_001144775; NM_001144776; NM_001144777; NM_001294348;
	NM_021952; NM_001324208; NM_001324209; NM_001324212; NM_001324213; NM_001324214; NM_001324215; NM_001324216; NM_001324217
NM_001038698; NM_001163397; NM_001163399; NM_010488; NM_001347178;
	NM_001357190
NP_001138246; NP_001138247; NP_001138248; NP_001138249; NP_001281277;
	NP_001311137; NP_001311138; NP_001311141; NP_001311142; NP_001311143; NP_001311144; NP_001311145; NP_001311146; NP_068771
NP_001033787; NP_001156869; NP_001156871; NP_001334107; NP_034618;
	NP_001344119
	Wikidata
View/Edit Human	View/Edit Mouse

HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.^[5]^[6]

The HuD/ELAVL4 protein is an RNA-binding protein.^[7] HuD contains three RRM protein domains, enabling RNA binding.^[8]

HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162374 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028546 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M (Dec 1993). "Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34". Cytogenet Cell Genet. 65 (3): 177–8. doi:10.1159/000133626. PMID 8222755.
^ "Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)".
^ Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal". Cell. 67 (2): 325–33. doi:10.1016/0092-8674(91)90184-Z. PMID 1655278. S2CID 26037558.
^ Lukong KE, Chang Kw, Khandjian EW, Richard S (2008-08-01). "RNA-binding proteins in human genetic disease". Trends in Genetics. 24 (8): 416–425. doi:10.1016/j.tig.2008.05.004. ISSN 0168-9525. PMID 18597886.
^ Nora Perrone-Bizzozero, Federico Bolognani (2002). "Role of HuD and other RNA-binding proteins in neural development and plasticity". J Neurosci Res. 68 (2): 121–126. doi:10.1002/jnr.10175. PMID 11948657.
^ Federico Bolognani, Nora Perrone-Bizzozero (2008). "RNA-protein interactions and control of mRNA stability in neurons". J Neurosci Res. 86 (3): 481–489. doi:10.1002/jnr.21473. PMID 17853436. S2CID 27076039.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162374 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028546 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8222755-5] Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M (Dec 1993). "Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34". Cytogenet Cell Genet. 65 (3): 177–8. doi:10.1159/000133626. PMID 8222755.

[entrez-6] "Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)".

[7] Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal". Cell. 67 (2): 325–33. doi:10.1016/0092-8674(91)90184-Z. PMID 1655278. S2CID 26037558.

[8] Lukong KE, Chang Kw, Khandjian EW, Richard S (2008-08-01). "RNA-binding proteins in human genetic disease". Trends in Genetics. 24 (8): 416–425. doi:10.1016/j.tig.2008.05.004. ISSN 0168-9525. PMID 18597886.

[9] Nora Perrone-Bizzozero, Federico Bolognani (2002). "Role of HuD and other RNA-binding proteins in neural development and plasticity". J Neurosci Res. 68 (2): 121–126. doi:10.1002/jnr.10175. PMID 11948657.

[10] Federico Bolognani, Nora Perrone-Bizzozero (2008). "RNA-protein interactions and control of mRNA stability in neurons". J Neurosci Res. 86 (3): 481–489. doi:10.1002/jnr.21473. PMID 17853436. S2CID 27076039.

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