Hydralazine/isosorbide dinitrate

Hydralazine/isosorbide dinitrate
Combination of
Isosorbide dinitrateVasodilator
HydralazineAntihypertensive
Clinical data
Trade namesBidil
License data
Routes of
administration
By mouth
ATC code
  • None
Legal status
Legal status
Identifiers
ChemSpider
KEGG
CompTox Dashboard (EPA)
 ☒NcheckY (what is this?)  (verify)

Hydralazine/isosorbide dinitrate, sold under the brand name Bidil, is a fixed-dose combination medication used to treat self-identified Black people with congestive heart failure.[1] It is a combination of hydralazine hydrochloride (an arteriolar vasodilator) and isosorbide dinitrate (a nitrate vasodilator).[1][2]

The American Food and Drug Administration (FDA) approved this race-specific medication to treat congestive heart failure in specifically self-identified Black patients. It provoked controversy as the first drug approved by the FDA marketed for a single racial-ethnic group.[3]

  1. ^ a b c "Bidil- hydralazine hydrochloride and isosorbide dinitrate tablet, film coated". DailyMed. U.S. National Library of Medicine. 26 January 2021. Retrieved 11 April 2022.
  2. ^ Ferdinand KC, Elkayam U, Mancini D, Ofili E, Piña I, Anand I, et al. (July 2014). "Use of isosorbide dinitrate and hydralazine in African-Americans with heart failure 9 years after the African-American Heart Failure Trial". The American Journal of Cardiology. 114 (1): 151–159. doi:10.1016/j.amjcard.2014.04.018. PMID 24846808.
  3. ^ Whitmarsh I, Jones DS, eds. (2010). "Governance and the Uses of Race" (PDF). What's the Use of Race?: Modern Governance and the Biology of Difference. Cambridge, MA: MIT Press. ISBN 978-0-262-51424-8. Archived from the original (PDF) on 5 March 2016. Retrieved 8 December 2013.* Panizzo R (21 November 2011). "Book Review: What's the Use of Race? Modern Governance and the Biology of Difference". BioNews. No. 634.