ID1

ID1
Identifiers
Aliases	ID1, ID, bHLHb24, inhibitor of DNA binding 1, HLH protein
External IDs	OMIM: 600349; MGI: 96396; HomoloGene: 1631; GeneCards: ID1; OMA:ID1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	31,606,515 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	152,579,330 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; right lung; ; right lobe of thyroid gland; ; olfactory zone of nasal mucosa; ; left lobe of thyroid gland; ; left uterine tube; ; tail of epididymis; ; mucosa of transverse colon; ; gastric mucosa; ; apex of heart;
	Top expressed in
	mucous cell of stomach; ; epithelium of stomach; ; optic nerve; ; maxillary prominence; ; choroid plexus of fourth ventricle; ; hand; ; molar; ; mandibular prominence; ; pyloric antrum; ; right lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein dimerization activity; DNA-binding transcription factor activity; protein self-association; protein C-terminus binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor binding; protein N-terminus binding; proteasome binding;
Cellular component	cytoplasm; centrosome; Golgi apparatus; nucleoplasm; nucleus;
Biological process	cell-abiotic substrate adhesion; cellular response to transforming growth factor beta stimulus; cellular response to nerve growth factor stimulus; cellular response to peptide; regulation of transcription, DNA-templated; regulation of MAPK cascade; blood vessel morphogenesis; lung morphogenesis; response to organic cyclic compound; blood vessel endothelial cell migration; positive regulation of epithelial cell proliferation; rhythmic process; cellular response to dopamine; response to antibiotic; negative regulation of DNA binding; endothelial cell morphogenesis; collagen metabolic process; negative regulation of apoptotic process; negative regulation of endothelial cell differentiation; negative regulation of transcription by RNA polymerase II; regulation of angiogenesis; negative regulation of protein binding; BMP signaling pathway; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; negative regulation of osteoblast differentiation; negative regulation of gene expression; cellular response to epidermal growth factor stimulus; multicellular organism development; heart development; brain development; positive regulation of gene expression; regulation of vasculature development; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; negative regulation of dendrite morphogenesis; circadian rhythm; protein destabilization; angiogenesis; neuron differentiation; negative regulation of protein homodimerization activity; positive regulation of actin filament bundle assembly; negative regulation of transcription by transcription factor localization; lung vasculature development; negative regulation of transcription, DNA-templated; transforming growth factor beta receptor signaling pathway; negative regulation of neuron differentiation; regulation of cell cycle; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3397
	15901
	ENSG00000125968
	ENSMUSG00000042745
	P41134
	P20067; Q6GTZ3
	NM_181353; NM_002165
	NM_010495; NM_001355113; NM_001369018
	NP_002156; NP_851998
	NP_034625; NP_001342042; NP_001355947
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125968 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042745 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H (April 1990). "The protein Id: a negative regulator of helix-loop-helix DNA binding proteins". Cell. 61 (1): 49–59. doi:10.1016/0092-8674(90)90214-Y. PMID 2156629. S2CID 29514374.
^ Hara E, Yamaguchi T, Nojima H, Ide T, Campisi J, Okayama H, Oda K (January 1994). "Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts". The Journal of Biological Chemistry. 269 (3): 2139–45. doi:10.1016/S0021-9258(17)42146-6. PMID 8294468.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125968 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042745 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[HalId-5] Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H (April 1990). "The protein Id: a negative regulator of helix-loop-helix DNA binding proteins". Cell. 61 (1): 49–59. doi:10.1016/0092-8674(90)90214-Y. PMID 2156629. S2CID 29514374.

[pmid8294468-6] Hara E, Yamaguchi T, Nojima H, Ide T, Campisi J, Okayama H, Oda K (January 1994). "Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts". The Journal of Biological Chemistry. 269 (3): 2139–45. doi:10.1016/S0021-9258(17)42146-6. PMID 8294468.

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