ID3 (gene)

ID3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LFH
Identifiers
Aliases	ID3, HEIR-1, bHLHb25, inhibitor of DNA binding 3, HLH protein
External IDs	OMIM: 600277; MGI: 96398; HomoloGene: 1633; GeneCards: ID3; OMA:ID3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	23,559,501 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	135,873,066 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; Descending thoracic aorta; ; left lobe of thyroid gland; ; ascending aorta; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; left coronary artery; ; left uterine tube; ; right auricle;
	Top expressed in
	endothelial cell of lymphatic vessel; ; otic placode; ; endocardial cushion; ; body of femur; ; medullary collecting duct; ; choroid plexus of fourth ventricle; ; hand; ; seminal vesicula; ; optic nerve; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; leptomycin B binding; transcription corepressor activity; protein domain specific binding; DNA-binding transcription factor activity; transcription factor binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	negative regulation of myoblast differentiation; regulation of transcription, DNA-templated; epithelial cell differentiation; rhythmic process; regulation of DNA replication; muscle organ development; notochord development; negative regulation of transcription by RNA polymerase II; negative regulation of DNA-binding transcription factor activity; negative regulation of osteoblast differentiation; transcription, DNA-templated; negative regulation of gene expression; regulation of cell cycle; odontogenesis; multicellular organism development; heart development; central nervous system development; response to wounding; circadian rhythm; neuron differentiation; positive regulation of apoptotic process; metanephros development; negative regulation of transcription, DNA-templated; cellular response to leptomycin B; negative regulation of DNA binding; negative regulation of neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3399
	15903
	ENSG00000283060; ENSG00000117318
	ENSMUSG00000007872
	Q02535
	P41133
	NM_002167
	NM_008321
	NP_002158
	NP_032347
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000117318 GRCh38: Ensembl release 89: ENSG00000283060, ENSG00000117318 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007872 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A (Aug 1992). "Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development". EMBO J. 11 (7): 2563–71. doi:10.1002/j.1460-2075.1992.tb05321.x. PMC 556731. PMID 1628620.
^ "Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein".

[refGRCh38Ensembl-1] ENSG00000117318 GRCh38: Ensembl release 89: ENSG00000283060, ENSG00000117318 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007872 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1628620-5] Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A (Aug 1992). "Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development". EMBO J. 11 (7): 2563–71. doi:10.1002/j.1460-2075.1992.tb05321.x. PMC 556731. PMID 1628620.

[entrez-6] "Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein".

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