IDH1

IDH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T09, 1T0L, 3INM, 3MAP, 3MAR, 3MAS, 4I3K, 4I3L, 4KZO, 4L03, 4L04, 4L06, 4UMX, 4UMY, 4XRX, 5DE1, 4XS3, 5K10, 5K11
Identifiers
Aliases	IDH1, HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD, isocitrate dehydrogenase (NADP(+)) 1, cytosolic, isocitrate dehydrogenase (NADP(+)) 1
External IDs	OMIM: 147700; MGI: 96413; HomoloGene: 21195; GeneCards: IDH1; OMA:IDH1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q34 Start 208,236,229 bp[1] End 208,266,074 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C2- C3|1 32.91 cM Start 65,197,775 bp[2] End 65,225,659 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis jejunal mucosa right adrenal cortex mucosa of sigmoid colon left adrenal gland left adrenal cortex secondary oocyte duodenum seminal vesicula caput epididymis Top expressed in cumulus cell transitional epithelium of urinary bladder right kidney medial ganglionic eminence left lobe of liver adrenal gland human kidney pyloric antrum barrel cortex superior cervical ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function magnesium ion binding protein homodimerization activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor signaling receptor binding isocitrate dehydrogenase (NADP+) activity oxidoreductase activity NAD binding isocitrate dehydrogenase activity NADP binding metal ion binding (R)-2-hydroxyglutarate dehydrogenase activity cadherin binding identical protein binding Cellular component peroxisome cytosol extracellular exosome peroxisomal matrix cytoplasm mitochondrion extracellular region secretory granule lumen tertiary granule lumen ficolin-1-rich granule lumen Biological process female gonad development NADPH regeneration response to oxidative stress response to organic cyclic compound response to steroid hormone 2-oxoglutarate metabolic process regulation of phospholipid catabolic process isocitrate metabolic process glyoxylate cycle tricarboxylic acid cycle regulation of phospholipid biosynthetic process glutathione metabolic process neutrophil degranulation protein targeting to peroxisome NADP metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3417 15926 Ensembl ENSG00000138413 ENSMUSG00000025950 UniProt O75874 O88844 RefSeq (mRNA) NM_005896 NM_001282386 NM_001282387 NM_001111320 NM_010497 RefSeq (protein) NP_001269315 NP_001269316 NP_005887 NP_001104790 NP_034627 Location (UCSC) Chr 2: 208.24 – 208.27 Mb Chr 1: 65.2 – 65.23 Mb PubMed search [3] [4]
Wikidata
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Isocitrate dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which uses NAD⁺ as the electron acceptor and the other NADP⁺. Five isocitrate dehydrogenases have been reported: three NAD⁺-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP⁺-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP⁺-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP⁺-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2,4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]^[5]