IDH2

IDH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JA8
Identifiers
Aliases	IDH2, D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH, isocitrate dehydrogenase (NADP(+)) 2, mitochondrial, isocitrate dehydrogenase (NADP(+)) 2, IDH-2
External IDs	OMIM: 147650; MGI: 96414; HomoloGene: 37590; GeneCards: IDH2; OMA:IDH2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 90,083,045 bp[1] End 90,102,477 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 D2|7 45.43 cM Start 79,744,594 bp[2] End 79,765,140 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastrocnemius muscle muscle of thigh body of tongue vastus lateralis muscle triceps brachii muscle left ventricle skeletal muscle tissue glutes Skeletal muscle tissue of biceps brachii Top expressed in right ventricle right kidney myocardium of ventricle cardiac muscle tissue of left ventricle atrium plantaris muscle soleus muscle atrioventricular valve thoracic diaphragm otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity isocitrate dehydrogenase activity NAD binding magnesium ion binding metal ion binding isocitrate dehydrogenase (NADP+) activity protein homodimerization activity Cellular component mitochondrial inner membrane cytosol mitochondrial matrix peroxisome extracellular exosome mitochondrion Biological process 2-oxoglutarate metabolic process glyoxylate cycle isocitrate metabolic process tricarboxylic acid cycle NADP biosynthetic process negative regulation of glial cell proliferation negative regulation of glial cell migration negative regulation of matrix metallopeptidase secretion mitochondrion organization carbohydrate metabolic process NADP metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3418 269951 Ensembl ENSG00000182054 ENSMUSG00000030541 UniProt P48735 P54071 RefSeq (mRNA) NM_002168 NM_001289910 NM_001290114 NM_173011 RefSeq (protein) NP_001276839 NP_001277043 NP_002159 NP_766599 Location (UCSC) Chr 15: 90.08 – 90.1 Mb Chr 7: 79.74 – 79.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Isocitrate dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene.^[5]

Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by the IDH2 gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.^[5] Somatic mosaic mutations of this gene have also been found associated to Ollier disease and Maffucci syndrome.^[6]