IFI16

IFI16
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2OQ0, 3B6Y, 3RLN, 3RLO, 3RNU, 4QGU
Identifiers
Aliases	IFI16, IFNGIP1, PYHIN2, interferon gamma inducible protein 16
External IDs	OMIM: 147586; MGI: 3695276; HomoloGene: 115929; GeneCards: IFI16; OMA:IFI16 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	159,055,155 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	173,426,840 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; pericardium; ; palpebral conjunctiva; ; Achilles tendon; ; lymph node; ; superficial temporal artery; ; vena cava; ; mucosa of nose; ; spleen; ; human penis;
	Top expressed in
	mesenteric lymph nodes; ; subcutaneous adipose tissue; ; spleen; ; thymus; ; bone marrow; ; white adipose tissue; ; blood; ; granulocyte; ; lumbar spinal ganglion; ; stroma of bone marrow;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding; double-stranded DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; transcription factor binding; protein binding; RNA binding;
Cellular component	nucleolus; nucleoplasm; nucleus; membrane; nuclear speck; cytoplasm; cytosol;
Biological process	positive regulation of type I interferon production; positive regulation of cytokine production; intrinsic apoptotic signaling pathway by p53 class mediator; cellular response to glucose starvation; transcription, DNA-templated; negative regulation of viral genome replication; negative regulation of innate immune response; monocyte differentiation; cellular response to ionizing radiation; negative regulation of DNA binding; regulation of autophagy; myeloid cell differentiation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; apoptotic process; hemopoiesis; activation of cysteine-type endopeptidase activity; autophagy; negative regulation of cysteine-type endopeptidase activity; negative regulation of transcription by RNA polymerase II; positive regulation of interleukin-1 beta production; regulation of transcription, DNA-templated; regulation of gene expression, epigenetic; cell population proliferation; positive regulation of transcription by RNA polymerase II; activation of innate immune response; immune system process; inflammatory response; negative regulation of transcription, DNA-templated; innate immune response; defense response to virus; cellular response to interferon-beta;
	Sources:Amigo / QuickGO
Orthologs
	3428
	623121
	ENSG00000163565
	ENSMUSG00000073491
	Q16666
	n/a
NM_001206567; NM_005531; NM_001364867; NM_001376587; NM_001376588;
	NM_001376589; NM_001376591; NM_001376592
	NM_001033384; NM_001177349; NM_001177350; NM_001368798; NM_001368799
NP_001193496; NP_005522; NP_001351796; NP_001363516; NP_001363517;
	NP_001363518; NP_001363520; NP_001363521
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163565 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073491 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Trapani JA, Browne KA, Dawson MJ, Ramsay RG, Eddy RL, Show TB, et al. (Oct 1992). "A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells". Immunogenetics. 36 (6): 369–376. doi:10.1007/bf00218044. PMID 1526658. S2CID 1196925.
^ Trapani JA, Dawson M, Apostolidis VA, Browne KA (Dec 1994). "Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization". Immunogenetics. 40 (6): 415–424. doi:10.1007/bf00177824. PMID 7959953. S2CID 2602156.
^ "Entrez Gene: IFI16 interferon, gamma-inducible protein 16".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163565 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073491 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1526658-5] Trapani JA, Browne KA, Dawson MJ, Ramsay RG, Eddy RL, Show TB, et al. (Oct 1992). "A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells". Immunogenetics. 36 (6): 369–376. doi:10.1007/bf00218044. PMID 1526658. S2CID 1196925.

[pmid7959953-6] Trapani JA, Dawson M, Apostolidis VA, Browne KA (Dec 1994). "Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization". Immunogenetics. 40 (6): 415–424. doi:10.1007/bf00177824. PMID 7959953. S2CID 2602156.

[entrez-7] "Entrez Gene: IFI16 interferon, gamma-inducible protein 16".

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