IGF2BP1

IGF2BP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KRM
Identifiers
Aliases	IGF2BP1, CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1, insulin like growth factor 2 mRNA binding protein 1
External IDs	OMIM: 608288; MGI: 1890357; HomoloGene: 4772; GeneCards: IGF2BP1; OMA:IGF2BP1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,056,145 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	96,005,940 bp
RNA expression pattern
	Top expressed in
	testicle; ; ganglionic eminence; ; gonad; ; ventricular zone; ; stromal cell of endometrium; ; buccal mucosa cell; ; right testis; ; left testis; ; placenta; ; retinal pigment epithelium;
	Top expressed in
	tail of embryo; ; abdominal wall; ; hand; ; epiblast; ; mandibular prominence; ; maxillary prominence; ; primitive streak; ; genital tubercle; ; yolk sac; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	translation regulator activity; mRNA 3'-UTR binding; protein binding; nucleic acid binding; mRNA 5'-UTR binding; mRNA binding; RNA binding;
Cellular component	cytoplasm; CRD-mediated mRNA stability complex; cell projection; filopodium; growth cone; dendritic spine; axon; dendrite; perinuclear region of cytoplasm; cytoplasmic stress granule; nucleus; lamellipodium; nucleoplasm; cytosol; ribonucleoprotein complex;
Biological process	CRD-mediated mRNA stabilization; mRNA transport; negative regulation of translation; pallium cell proliferation in forebrain; neuronal stem cell population maintenance; RNA localization; regulation of translation; regulation of mRNA stability involved in response to stress; regulation of mRNA stability; transport;
	Sources:Amigo / QuickGO
Orthologs
	10642
	140486
	ENSG00000159217
	ENSMUSG00000013415
	Q9NZI8
	O88477
	NM_001160423; NM_006546
	NM_009951
	NP_001153895; NP_006537
	NP_034081; NP_001388383; NP_001388384; NP_001388385; NP_001388386
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.^[5]^[6]^[7]

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159217 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000013415 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC 116055. PMID 9891060.
^ Yaniv K, Yisraeli JK (May 2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis". Gene. 287 (1–2): 49–54. doi:10.1016/S0378-1119(01)00866-6. PMID 11992722.
^ ^a ^b "Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159217 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000013415 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9891060-5] Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC 116055. PMID 9891060.

[pmid11992722-6] Yaniv K, Yisraeli JK (May 2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis". Gene. 287 (1–2): 49–54. doi:10.1016/S0378-1119(01)00866-6. PMID 11992722.

[entrez-7] "Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1".

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