IGFBP7

IGFBP7
Identifiers
Aliases	IGFBP7, AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF, insulin like growth factor binding protein 7
External IDs	OMIM: 602867; MGI: 1352480; HomoloGene: 1193; GeneCards: IGFBP7; OMA:IGFBP7 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	57,110,385 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	77,555,888 bp
RNA expression pattern
	Top expressed in
	vena cava; ; renal medulla; ; saphenous vein; ; Epithelium of choroid plexus; ; pericardium; ; superficial temporal artery; ; Descending thoracic aorta; ; right coronary artery; ; urethra; ; ascending aorta;
	Top expressed in
	ascending aorta; ; aortic valve; ; epithelium of lens; ; right kidney; ; tunica media of zone of aorta; ; proximal tubule; ; renal corpuscle; ; carotid body; ; right lung; ; mesenteric lymph nodes;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; growth factor binding; insulin-like growth factor binding; extracellular matrix structural constituent;
Cellular component	extracellular matrix; extracellular exosome; extracellular space; endoplasmic reticulum lumen; extracellular region; collagen-containing extracellular matrix;
Biological process	regulation of cell growth; negative regulation of cell population proliferation; cell adhesion; response to retinoic acid; cellular response to hormone stimulus; regulation of steroid biosynthetic process; response to heat; embryo implantation; response to organic cyclic compound; response to cortisol; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	3490
	29817
	ENSG00000163453
	ENSMUSG00000036256
	Q16270
	Q61581
	NM_001553; NM_001253835
	NM_001159518; NM_008048
	NP_001240764; NP_001544
	NP_001152990; NP_032074
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor-binding protein 7 is a protein that in humans is encoded by the IGFBP7 gene.^[5]^[6]^[7] The major function of the protein is the regulation of availability of insulin-like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors. IGFBP7 binds to IGF with low affinity compared to IGFBPs 1-6.^[8]^[9] It also stimulates cell adhesion. The protein is implicated in some cancers.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163453 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036256 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Murphy M, Pykett MJ, Harnish P, Zang KD, George DL (Dec 1993). "Identification and characterization of genes differentially expressed in meningiomas". Cell Growth Differ. 4 (9): 715–22. PMID 7694637.
^ Yamauchi T, Umeda F, Masakado M, Isaji M, Mizushima S, Nawata H (Nov 1994). "Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells". Biochem J. 303 (2): 591–8. doi:10.1042/bj3030591. PMC 1137368. PMID 7980422.
^ "Entrez Gene: IGFBP7 insulin-like growth factor binding protein 7".
^ Oh Y, Nagalla SR, Yamanaka Y, Kim HS, Wilson E, Rosenfeld RG (November 1996). "Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II". J. Biol. Chem. 271 (48): 30322–5. doi:10.1074/jbc.271.48.30322. PMID 8939990.
^ Kim HS, Rosenfeld RG, Oh Y (June 1997). "Biological roles of insulin-like growth factor binding proteins (IGFBPs)". Experimental & Molecular Medicine. 29 (2): 85–96. doi:10.1038/emm.1997.13. ISSN 2092-6413. S2CID 12150421.
^ Gommans WM, Tatalias NE, Sie CP, Dupuis D, Vendetti N, Smith L, Kaushal R, Maas S (October 2008). "Screening of human SNP database identifies recoding sites of A-to-I RNA editing". RNA. 14 (10): 2074–85. doi:10.1261/rna.816908. PMC 2553741. PMID 18772245.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163453 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036256 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7694637-5] Murphy M, Pykett MJ, Harnish P, Zang KD, George DL (Dec 1993). "Identification and characterization of genes differentially expressed in meningiomas". Cell Growth Differ. 4 (9): 715–22. PMID 7694637.

[pmid7980422-6] Yamauchi T, Umeda F, Masakado M, Isaji M, Mizushima S, Nawata H (Nov 1994). "Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells". Biochem J. 303 (2): 591–8. doi:10.1042/bj3030591. PMC 1137368. PMID 7980422.

[entrez-7] "Entrez Gene: IGFBP7 insulin-like growth factor binding protein 7".

[pmid8939990-8] Oh Y, Nagalla SR, Yamanaka Y, Kim HS, Wilson E, Rosenfeld RG (November 1996). "Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II". J. Biol. Chem. 271 (48): 30322–5. doi:10.1074/jbc.271.48.30322. PMID 8939990.

[9] Kim HS, Rosenfeld RG, Oh Y (June 1997). "Biological roles of insulin-like growth factor binding proteins (IGFBPs)". Experimental & Molecular Medicine. 29 (2): 85–96. doi:10.1038/emm.1997.13. ISSN 2092-6413. S2CID 12150421.

[pmid18772245-10] Gommans WM, Tatalias NE, Sie CP, Dupuis D, Vendetti N, Smith L, Kaushal R, Maas S (October 2008). "Screening of human SNP database identifies recoding sites of A-to-I RNA editing". RNA. 14 (10): 2074–85. doi:10.1261/rna.816908. PMC 2553741. PMID 18772245.

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