IKBKE

IKBKE
Identifiers
Aliases	IKBKE, IKK-E, IKK-i, IKKE, IKKI, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon, inhibitor of nuclear factor kappa B kinase subunit epsilon
External IDs	OMIM: 605048; MGI: 1929612; HomoloGene: 23168; GeneCards: IKBKE; OMA:IKBKE - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,496,889 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	131,207,344 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; granulocyte; ; monocyte; ; blood; ; lymph node; ; bone marrow cells; ; appendix; ; mucosa of esophagus; ; tonsil; ; mucosa of transverse colon;
	Top expressed in
	mesenteric lymph nodes; ; crypt of lieberkuhn of small intestine; ; thymus; ; stroma of bone marrow; ; granulocyte; ; jejunum; ; duodenum; ; ileum; ; blood; ; choroidal fissure;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; IkappaB kinase activity; nucleotide binding; K48-linked polyubiquitin modification-dependent protein binding; kinase activity; protein serine/threonine kinase activity; NF-kappaB-inducing kinase activity; K63-linked polyubiquitin modification-dependent protein binding; protein binding; ATP binding; ubiquitin protein ligase binding; protein kinase activity; protein phosphatase binding;
Cellular component	cytoplasm; cytosol; PML body; mitochondrial membranes; endosome membrane; nucleus; nucleoplasm;
Biological process	cellular response to virus; phosphorylation; I-kappaB phosphorylation; response to interferon-beta; cellular response to DNA damage stimulus; TRIF-dependent toll-like receptor signaling pathway; protein phosphorylation; response to type I interferon; immune response; intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of type I interferon production; protein homooligomerization; NIK/NF-kappaB signaling; positive regulation of lipid storage; peptidyl-serine phosphorylation; innate immune response; viral process; positive regulation of type I interferon-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9641
	56489
	ENSG00000263528
	ENSMUSG00000042349
	Q14164
	Q9R0T8
	NM_001193321; NM_001193322; NM_014002
	NM_019777
	NP_001180250; NP_001180251; NP_054721
	NP_062751
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibitor of nuclear factor kappa-B kinase subunit epsilon also known as I-kappa-B kinase epsilon or IKK-epsilon is an enzyme that in humans is encoded by the IKBKE gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000263528 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042349 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, Kanamaru A, Akira S (September 1999). "IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases". Int Immunol. 11 (8): 1357–62. doi:10.1093/intimm/11.8.1357. PMID 10421793.
^ Peters RT, Liao SM, Maniatis T (July 2000). "IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex". Mol Cell. 5 (3): 513–22. doi:10.1016/S1097-2765(00)80445-1. PMID 10882136.
^ "Entrez Gene: IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000263528 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042349 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10421793-5] Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, Kanamaru A, Akira S (September 1999). "IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases". Int Immunol. 11 (8): 1357–62. doi:10.1093/intimm/11.8.1357. PMID 10421793.

[pmid10882136-6] Peters RT, Liao SM, Maniatis T (July 2000). "IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex". Mol Cell. 5 (3): 513–22. doi:10.1016/S1097-2765(00)80445-1. PMID 10882136.

[entrez-7] "Entrez Gene: IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon".

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