IKZF1

IKZF1
Identifiers
Aliases	IKZF1, Hs.54452, IK1, IKAROS, LYF1, LyF-1, PPP1R92, PRO0758, ZNFN1A1, CVID13, IKAROS family zinc finger 1
External IDs	OMIM: 603023; MGI: 1342540; HomoloGene: 55948; GeneCards: IKZF1; OMA:IKZF1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	50,405,101 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	11,722,926 bp
RNA expression pattern
	Top expressed in
	white blood cell; ; monocyte; ; bone marrow; ; trabecular bone; ; blood; ; granulocyte; ; bone marrow cells; ; lymph node; ; epithelium of nasopharynx; ; thymus;
	Top expressed in
	thymus; ; granulocyte; ; blood; ; mesenteric lymph nodes; ; spleen; ; submandibular gland; ; stroma of bone marrow; ; subcutaneous adipose tissue; ; embryo; ; yolk sac;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; metal ion binding; nucleic acid binding; protein domain specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; nucleoplasm; protein-containing complex;
Biological process	erythrocyte differentiation; cell cycle; multicellular organism development; mesoderm development; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; lymphocyte differentiation; protein heterooligomerization; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	10320
	22778
	ENSG00000185811
	ENSMUSG00000018654
	Q13422
	Q03267
NM_001220765; NM_001220766; NM_001220767; NM_001220768; NM_001220769;
	NM_001220770; NM_001220771; NM_001220772; NM_001220773; NM_001220774; NM_001220775; NM_001220776; NM_001291837; NM_001291838; NM_001291839; NM_001291840; NM_001291841; NM_001291842; NM_001291843; NM_001291844; NM_001291845; NM_001291846; NM_001291847; NM_006060
NM_001025597; NM_001301863; NM_001301865; NM_001301866; NM_001301868;
	NM_009578
NP_001207694; NP_001207696; NP_001207697; NP_001207699; NP_001207700;
	NP_001278766; NP_001278767; NP_001278768; NP_001278769; NP_001278770; NP_001278771; NP_001278772; NP_001278773; NP_001278774; NP_001278775; NP_001278776; NP_006051
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185811 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018654 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Georgopoulos K, Moore DD, Derfler B (October 1992). "Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment". Science. 258 (5083): 808–12. Bibcode:1992Sci...258..808G. doi:10.1126/science.1439790. PMID 1439790.
^ Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST (November 1994). "The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene". Molecular and Cellular Biology. 14 (11): 7111–23. doi:10.1128/mcb.14.11.7111. PMC 359245. PMID 7935426.
^ "Entrez Gene: IKZF1 IKAROS family zinc finger 1 (Ikaros)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185811 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018654 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1439790-5] Georgopoulos K, Moore DD, Derfler B (October 1992). "Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment". Science. 258 (5083): 808–12. Bibcode:1992Sci...258..808G. doi:10.1126/science.1439790. PMID 1439790.

[pmid7935426-6] Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST (November 1994). "The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene". Molecular and Cellular Biology. 14 (11): 7111–23. doi:10.1128/mcb.14.11.7111. PMC 359245. PMID 7935426.

[entrez-7] "Entrez Gene: IKZF1 IKAROS family zinc finger 1 (Ikaros)".

[1]

[2]

[3]

[4]

[5]

[6]

[7]