IKZF2

IKZF2
Identifiers
Aliases	IKZF2, ANF1A2, HELIOS, ZNF1A2, ZNFN1A2, IKAROS family zinc finger 2
External IDs	OMIM: 606234; MGI: 1342541; HomoloGene: 22659; GeneCards: IKZF2; OMA:IKZF2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	213,152,427 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	69,726,404 bp
RNA expression pattern
	Top expressed in
	thymus; ; palpebral conjunctiva; ; amniotic fluid; ; mucosa of pharynx; ; oral cavity; ; gingival epithelium; ; pancreatic epithelial cell; ; mucosa of paranasal sinus; ; epithelium of nasopharynx; ; skin of thigh;
	Top expressed in
	conjunctival fornix; ; gastrula; ; submandibular gland; ; transitional epithelium of urinary bladder; ; cornea; ; lobe of prostate; ; otolith organ; ; utricle; ; skin of external ear; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; protein homodimerization activity; metal ion binding; protein heterodimerization activity; nucleic acid binding; molecular function; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; biological process;
	Sources:Amigo / QuickGO
Orthologs
	22807
	22779
	ENSG00000030419
	ENSMUSG00000025997
	Q9UKS7
	P81183
NM_001079526; NM_016260; NM_001371274; NM_001371275; NM_001371276;
	NM_001371277; NM_001387220
	NM_011770
NP_001072994; NP_057344; NP_001358203; NP_001358204; NP_001358205;
	NP_001358206
NP_035900; NP_001389779; NP_001389781; NP_001389782; NP_001389783;
	NP_001389784; NP_001389785; NP_001389786
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene.^[5]^[6]^[7] This protein is a member of Ikaros family of transcription factors.^[8]

This gene encodes a member of the Ikaros family of zinc-finger proteins. This family of transcription factors consists of five members: Ikaros (Ikzf1), Helios (Ikzf2), Aiolos (Ikzf3), Eos (Ikzf4), and Pegasus (Ikzf5). The Ikaros family members are involved in the hematopoietic development, some to a greater extent than others with Ikaros being expressed in all hematopoietic cells.^[8] This protein forms homo- or hetero-dimers with other Ikaros family members. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological relevance of some variants has not been determined.^[7]

When these factors are missing or altered, lymphocytes suffer from defective development. Since Ikaros family members can interact with each other, it is probable that when one transcription factor is defected, others can substitute it. Because of this, it is rather difficult to assess precise function to each transcription factor.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000030419 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025997 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, et al. (March 1998). "Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin". Genes & Development. 12 (6): 782–796. doi:10.1101/gad.12.6.782. PMC 316626. PMID 9512513.
^ Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA (April 1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors". Current Biology. 8 (9): 508–515. Bibcode:1998CBio....8..508K. doi:10.1016/S0960-9822(98)70202-7. PMID 9560339.
^ ^a ^b "Entrez Gene: IKZF2 IKAROS family zinc finger 2 (Helios)".
^ ^a ^b Thornton AM, Shevach EM (November 2019). "Helios: still behind the clouds". Immunology. 158 (3): 161–170. doi:10.1111/imm.13115. PMC 6797934. PMID 31517385.
^ Read KA, Jones DM, Freud AG, Oestreich KJ (March 2021). "Established and emergent roles for Ikaros transcription factors in lymphoid cell development and function". Immunological Reviews. 300 (1): 82–99. doi:10.1111/imr.12936. PMC 8015388. PMID 33331000.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000030419 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025997 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9512513-5] Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, et al. (March 1998). "Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin". Genes & Development. 12 (6): 782–796. doi:10.1101/gad.12.6.782. PMC 316626. PMID 9512513.

[pmid9560339-6] Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA (April 1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors". Current Biology. 8 (9): 508–515. Bibcode:1998CBio....8..508K. doi:10.1016/S0960-9822(98)70202-7. PMID 9560339.

[entrez-7] "Entrez Gene: IKZF2 IKAROS family zinc finger 2 (Helios)".

[:0-8] Thornton AM, Shevach EM (November 2019). "Helios: still behind the clouds". Immunology. 158 (3): 161–170. doi:10.1111/imm.13115. PMC 6797934. PMID 31517385.

[:1-9] Read KA, Jones DM, Freud AG, Oestreich KJ (March 2021). "Established and emergent roles for Ikaros transcription factors in lymphoid cell development and function". Immunological Reviews. 300 (1): 82–99. doi:10.1111/imr.12936. PMC 8015388. PMID 33331000.

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