IL17RB

IL17RB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL17RB, CRL4, EVI27, IL17BR, IL17RH1, interleukin 17 receptor B
External IDsOMIM: 605458; MGI: 1355292; HomoloGene: 10287; GeneCards: IL17RB; OMA:IL17RB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018725
NM_172234

NM_019583

RefSeq (protein)

NP_061195

NP_062529

Location (UCSC)Chr 3: 53.85 – 53.87 MbChr 14: 29.72 – 29.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.[5][6][7]

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000056736Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015966Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (Aug 2000). "A novel cytokine receptor-ligand pair. Identification, molecular Aaron 9 ok ò charkacterization, and in vivo immunomodulatory activity". J Biol Chem. 275 (25): 19167–76. doi:10.1074/jbc.M910228199. PMID 10749887.
  6. ^ Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr (Jun 2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor". Oncogene. 19 (17): 2098–109. doi:10.1038/sj.onc.1203577. PMID 10815801. S2CID 27521628.
  7. ^ a b "Entrez Gene: IL17RB interleukin 17 receptor B".