IL2RA

IL2RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z92, 2B5I, 2ERJ, 3IU3, 3NFP
Identifiers
Aliases	IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
External IDs	OMIM: 147730; MGI: 96549; HomoloGene: 360; GeneCards: IL2RA; OMA:IL2RA - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.1 Start 6,010,689 bp[1] End 6,062,370 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A1|2 8.91 cM Start 11,647,618 bp[2] End 11,698,004 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node appendix spleen buccal mucosa cell gallbladder blood granulocyte epithelium of colon smooth muscle tissue tonsil Top expressed in thymus zygote secondary oocyte granulocyte lymph node muscle of thigh blood primary oocyte sternocleidomastoid muscle esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-2 receptor activity interleukin-2 binding protein binding Cellular component integral component of membrane membrane plasma membrane cell surface external side of plasma membrane intracellular anatomical structure interleukin-2 receptor complex Biological process Notch signaling pathway positive regulation of T cell differentiation regulation of T cell tolerance induction inflammatory response to antigenic stimulus negative regulation of defense response to virus immune system process activation-induced cell death of T cells negative regulation of lymphocyte proliferation MAPK cascade T cell homeostasis regulation of T cell homeostatic proliferation cell surface receptor signaling pathway negative regulation of T cell proliferation negative regulation of immune response immune response positive regulation of T cell proliferation cell population proliferation inflammatory response negative regulation of inflammatory response positive regulation of activated T cell proliferation apoptotic process regulation of regulatory T cell differentiation cytokine-mediated signaling pathway interleukin-2-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3559 16184 Ensembl ENSG00000134460 ENSMUSG00000026770 UniProt P01589 P01590 RefSeq (mRNA) NM_000417 NM_001308242 NM_001308243 NM_008367 RefSeq (protein) NP_000408 NP_001295171 NP_001295172 NP_032393 Location (UCSC) Chr 10: 6.01 – 6.06 Mb Chr 2: 11.65 – 11.7 Mb PubMed search [3] [4]
Wikidata
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The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates, this receptor interacts with interleukin-2, a pleiotropic cytokine which plays an important role in immune homeostasis.^[5][6]