IL2RA

IL2RA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
External IDsOMIM: 147730; MGI: 96549; HomoloGene: 360; GeneCards: IL2RA; OMA:IL2RA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000417
NM_001308242
NM_001308243

NM_008367

RefSeq (protein)

NP_000408
NP_001295171
NP_001295172

NP_032393

Location (UCSC)Chr 10: 6.01 – 6.06 MbChr 2: 11.65 – 11.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates, this receptor interacts with interleukin-2, a pleiotropic cytokine which plays an important role in immune homeostasis.[5][6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134460Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026770Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Spolski R, Li P, Leonard WJ (October 2018). "Biology and regulation of IL-2: from molecular mechanisms to human therapy". Nature Reviews. Immunology. 18 (10): 648–659. doi:10.1038/s41577-018-0046-y. PMID 30089912. S2CID 51939991.
  6. ^ Zhou P (October 2022). "Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity". Cytokine & Growth Factor Reviews. 67: 80–88. doi:10.1016/j.cytogfr.2022.06.003. PMID 35803833. S2CID 250200065.