ING2

ING2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WES, 2G6Q
Identifiers
Aliases	ING2, ING1L, p33inhibitor of growth family member 2
External IDs	OMIM: 604215; MGI: 1916510; HomoloGene: 20388; GeneCards: ING2; OMA:ING2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	183,512,429 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	48,128,591 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; jejunal mucosa; ; right adrenal gland; ; right adrenal cortex; ; buccal mucosa cell; ; left adrenal gland; ; left adrenal cortex; ; gonad; ; palpebral conjunctiva; ; bronchial epithelial cell;
	Top expressed in
	lens; ; epithelium of lens; ; islet of Langerhans; ; granulocyte; ; epiblast; ; seminiferous tubule; ; renal corpuscle; ; neural layer of retina; ; yolk sac; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; chromatin binding; metal ion binding; methylated histone binding; protein binding; phosphatidylinositol binding; protein-containing complex binding;
Cellular component	Golgi apparatus; plasma membrane; Sin3 complex; CCAAT-binding factor complex; nucleus; nucleoplasm; cytosol;
Biological process	flagellated sperm motility; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of transcription, DNA-templated; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of apoptotic signaling pathway; male meiosis I; transcription, DNA-templated; positive regulation of transcription, DNA-templated; male germ-line stem cell asymmetric division; seminiferous tubule development; spermatogenesis; spermatid development; regulation of growth; regulation of response to DNA damage stimulus; signal transduction; negative regulation of cell population proliferation; chromatin organization; positive regulation of histone deacetylation; regulation of apoptotic process; regulation of cellular senescence;
	Sources:Amigo / QuickGO
Orthologs
	3622
	69260
	ENSG00000168556
	ENSMUSG00000063049
	Q9H160
	Q9ESK4
	NM_001291959; NM_001564
	NM_023503
	NP_001278888; NP_001555
	NP_075992
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibitor of growth protein 2 is a protein that in humans is encoded by the ING2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168556 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063049 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shimada Y, Saito A, Suzuki M, Takahashi E, Horie M (Mar 1999). "Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor". Cytogenetics and Cell Genetics. 83 (3–4): 232–5. doi:10.1159/000015188. PMID 10072587. S2CID 7081905.
^ "Entrez Gene: ING2 inhibitor of growth family, member 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168556 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063049 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10072587-5] Shimada Y, Saito A, Suzuki M, Takahashi E, Horie M (Mar 1999). "Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor". Cytogenetics and Cell Genetics. 83 (3–4): 232–5. doi:10.1159/000015188. PMID 10072587. S2CID 7081905.

[entrez-6] "Entrez Gene: ING2 inhibitor of growth family, member 2".

[1]

[2]

[3]

[4]

[5]

[6]