ING4

ING4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K1J, 2M1R, 2PNX, 2VNF, 4AFL
Identifiers
Aliases	ING4, my036, p29inhibitor of growth family member 4
External IDs	OMIM: 608524; MGI: 107307; HomoloGene: 22952; GeneCards: ING4; OMA:ING4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,663,142 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	125,026,228 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; monocyte; ; ventricular zone; ; right hemisphere of cerebellum; ; right uterine tube; ; granulocyte; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; C1 segment; ; muscle layer of sigmoid colon;
	Top expressed in
	granulocyte; ; ventricular zone; ; lip; ; neural layer of retina; ; thin ascending limb of loop of Henle; ; right kidney; ; spermatocyte; ; muscle of thigh; ; morula; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; metal ion binding; methylated histone binding; protein binding;
Cellular component	histone acetyltransferase complex; nucleus; nucleoplasm; cytosol; intermediate filament cytoskeleton;
Biological process	negative regulation of growth; histone H4-K5 acetylation; DNA replication; histone acetylation; histone H3 acetylation; positive regulation of apoptotic process; histone H4-K16 acetylation; cell cycle; negative regulation of transcription, DNA-templated; histone H4-K8 acetylation; histone H4-K12 acetylation; negative regulation of cell population proliferation; protein acetylation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; apoptotic process; chromatin organization; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	51147
	28019
	ENSG00000111653
	ENSMUSG00000030330
	Q9UNL4
	Q8C0D7
NM_001127582; NM_001127583; NM_001127584; NM_001127585; NM_001127586;
	NM_016162; NM_198287
	NM_133345; NM_144510; NM_001368695
NP_001121054; NP_001121055; NP_001121056; NP_001121057; NP_001121058;
	NP_057246
	NP_579923; NP_001355624
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111653 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030330 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Research. 63 (10): 2373–8. PMID 12750254.
^ "Entrez Gene: ING4 inhibitor of growth family, member 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111653 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030330 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12750254-5] Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Research. 63 (10): 2373–8. PMID 12750254.

[entrez-6] "Entrez Gene: ING4 inhibitor of growth family, member 4".

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