INHBB

INHBB
Identifiers
Aliases	INHBB, inhibin beta B subunit, inhibin subunit beta B
External IDs	OMIM: 147390; MGI: 96571; HomoloGene: 1654; GeneCards: INHBB; OMA:INHBB - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	120,351,803 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	119,349,978 bp
RNA expression pattern
	Top expressed in
	pericardium; ; ventricular zone; ; lactiferous duct; ; bronchial epithelial cell; ; subcutaneous adipose tissue; ; mucosa of paranasal sinus; ; abdominal fat; ; ganglionic eminence; ; left lobe of thyroid gland; ; skin of leg;
	Top expressed in
	cervix; ; Gonadal ridge; ; decidua; ; cumulus cell; ; membrana granulosa of ovarian follicle; ; calvaria; ; ventricular zone; ; white adipose tissue; ; ciliary body; ; pineal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	host cell surface receptor binding; cytokine activity; protein homodimerization activity; hormone activity; protein binding; transforming growth factor beta receptor binding; growth factor activity;
Cellular component	extracellular region; perinuclear region of cytoplasm; cell periphery; extracellular space;
Biological process	regulation of apoptotic process; defense response; cell differentiation; negative regulation of insulin secretion; regulation of MAPK cascade; SMAD protein signal transduction; cell development; cellular response to starvation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of apoptotic signaling pathway; positive regulation of follicle-stimulating hormone secretion; cellular response to leptin stimulus; oocyte development; positive regulation of ovulation; cellular response to insulin stimulus; ovarian follicle development; negative regulation of follicle-stimulating hormone secretion; fat cell differentiation; activin receptor signaling pathway; regulation of signaling receptor activity; adhesion of symbiont to host cell; response to wounding;
	Sources:Amigo / QuickGO
Orthologs
	3625
	16324
	ENSG00000163083
	ENSMUSG00000037035
	P09529
	Q04999
	NM_002193
	NM_008381
	NP_002184
	NP_032407
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibin, beta B, also known as INHBB, is a protein which in humans is encoded by the INHBB gene.^[5]^[6] INHBB is a subunit of both activin and inhibin, two closely related glycoproteins with opposing biological effects.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163083 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037035 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Burger HG, Igarashi M (April 1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology. 122 (4): 1701–2. doi:10.1210/endo-122-4-1701. PMID 3345731.
^ "Entrez Gene: INHBB inhibin, beta B (activin AB beta polypeptide)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163083 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037035 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3345731-5] Burger HG, Igarashi M (April 1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology. 122 (4): 1701–2. doi:10.1210/endo-122-4-1701. PMID 3345731.

[entrez-6] "Entrez Gene: INHBB inhibin, beta B (activin AB beta polypeptide)".

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