INSL4

INSL4
Identifiers
Aliases	INSL4, EPIL, PLACENTIN, insulin like 4
External IDs	OMIM: 600910; HomoloGene: 88662; GeneCards: INSL4; OMA:INSL4 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	5,235,304 bp
RNA expression pattern
	Top expressed in
	placenta; ; gonad; ; corpus epididymis; ; stromal cell of endometrium; ; cecum; ; appendix; ; liver; ; smooth muscle tissue; ; right lobe of liver; ; popliteal artery;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; insulin-like growth factor receptor binding; hormone activity;
Cellular component	extracellular region; extracellular space;
Biological process	multicellular organism development; female pregnancy; cell-cell signaling; cell population proliferation; signal transduction; regulation of signaling receptor activity; positive regulation of chorionic trophoblast cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3641
	n/a
	ENSG00000120211
	n/a
	Q14641
	n/a
	NM_002195
	n/a
	NP_002186
	n/a
	Wikidata
View/Edit Human

Early placenta insulin-like peptide is a protein that in humans is encoded by the INSL4 gene.^[3]^[4]^[5]

INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120211 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chassin D, Laurent A, Janneau JL, Berger R, Bellet D (Aug 1996). "Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta". Genomics. 29 (2): 465–70. doi:10.1006/geno.1995.9980. PMID 8666396.
^ Veitia R, Laurent A, Quintana-Murci L, Ottolenghi C, Fellous M, Vidaud M, McElreavey K (Oct 1998). "The INSL4 gene maps close to WI-5527 at 9p24.1→p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome". Cytogenet Cell Genet. 81 (3–4): 275–7. doi:10.1159/000015045. PMID 9730618. S2CID 46801238.
^ ^a ^b "Entrez Gene: INSL4 insulin-like 4 (placenta)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120211 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8666396-3] Chassin D, Laurent A, Janneau JL, Berger R, Bellet D (Aug 1996). "Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta". Genomics. 29 (2): 465–70. doi:10.1006/geno.1995.9980. PMID 8666396.

[pmid9730618-4] Veitia R, Laurent A, Quintana-Murci L, Ottolenghi C, Fellous M, Vidaud M, McElreavey K (Oct 1998). "The INSL4 gene maps close to WI-5527 at 9p24.1→p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome". Cytogenet Cell Genet. 81 (3–4): 275–7. doi:10.1159/000015045. PMID 9730618. S2CID 46801238.

[entrez-5] "Entrez Gene: INSL4 insulin-like 4 (placenta)".

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