IRF5

IRF5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DSH
Identifiers
Aliases	IRF5, SLEB10, interferon regulatory factor 5
External IDs	OMIM: 607218; MGI: 1350924; HomoloGene: 8088; GeneCards: IRF5; OMA:IRF5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	128,950,038 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	29,541,870 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; spleen; ; blood; ; bone marrow cells; ; lymph node; ; upper lobe of left lung; ; testicle; ; right uterine tube; ; right coronary artery;
	Top expressed in
	mesenteric lymph nodes; ; stroma of bone marrow; ; granulocyte; ; spleen; ; lip; ; right kidney; ; female urethra; ; proximal tubule; ; esophagus; ; blastocyst;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; protein binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	regulation of transcription, DNA-templated; positive regulation of interleukin-12 production; interferon-gamma-mediated signaling pathway; immune system process; regulation of transcription by RNA polymerase II; positive regulation of interferon-alpha production; response to muramyl dipeptide; transcription, DNA-templated; defense response to virus; type I interferon signaling pathway; response to peptidoglycan; positive regulation of apoptotic process; innate immune response; positive regulation of transcription by RNA polymerase II; positive regulation of interferon-beta production; cytokine-mediated signaling pathway; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3663
	27056
	ENSG00000128604
	ENSMUSG00000029771
	Q13568
	P56477
NM_001098627; NM_001098629; NM_001098630; NM_001242452; NM_032643;
	NM_001347928; NM_001364314
	NM_001252382; NM_012057; NM_001311083
NP_001092097; NP_001092099; NP_001092100; NP_001229381; NP_116032;
	NP_001334857; NP_001351243; NP_001092099.1
	NP_001239311; NP_001298012; NP_036187
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene.^[5] The IRF family is a group of transcription factors that are involved in signaling for virus responses in mammals along with regulation of certain cellular functions.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128604 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029771 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IRF5 interferon regulatory factor 5".
^ Negishi H, Taniguchi T, Yanai H (November 2018). "The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family". Cold Spring Harbor Perspectives in Biology. 10 (11): a028423. doi:10.1101/cshperspect.a028423. PMC 6211389. PMID 28963109.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128604 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029771 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IRF5 interferon regulatory factor 5".

[:0-6] Negishi H, Taniguchi T, Yanai H (November 2018). "The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family". Cold Spring Harbor Perspectives in Biology. 10 (11): a028423. doi:10.1101/cshperspect.a028423. PMC 6211389. PMID 28963109.

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