IRF7

IRF7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2O61
Identifiers
Aliases	IRF7, IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H, IMD39, interferon regulatory factor 7, IRF-7
External IDs	OMIM: 605047; MGI: 1859212; HomoloGene: 128624; GeneCards: IRF7; OMA:IRF7 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	615,983 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,846,394 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; right lobe of liver; ; spleen; ; monocyte; ; mucosa of transverse colon; ; apex of heart; ; lymph node; ; bone marrow; ; bone marrow cells;
	Top expressed in
	granulocyte; ; gastrula; ; blood; ; mucous cell of stomach; ; ileum; ; jejunum; ; duodenum; ; large intestine; ; colon; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; protein binding; RNA polymerase II core promoter sequence-specific DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleoplasm; endosome membrane; nucleus; cytoplasm; cytosol;
Biological process	positive regulation of type I interferon-mediated signaling pathway; regulation of transcription, DNA-templated; positive regulation of interferon-alpha production; MDA-5 signaling pathway; interferon-gamma-mediated signaling pathway; immune system process; regulation of adaptive immune response; response to virus; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; regulation of type I interferon production; cellular response to DNA damage stimulus; TRIF-dependent toll-like receptor signaling pathway; positive regulation of transcription, DNA-templated; negative regulation of macrophage apoptotic process; type I interferon signaling pathway; immunoglobulin mediated immune response; establishment of viral latency; regulation of immune response; viral process; regulation of monocyte differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of interferon-beta production; interferon-beta production; regulation of MyD88-independent toll-like receptor signaling pathway; positive regulation of type I interferon production; innate immune response; regulation of MyD88-dependent toll-like receptor signaling pathway; interferon-alpha production; defense response to virus; regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	3665
	54123
	ENSG00000276561; ENSG00000185507
	ENSMUSG00000025498
	Q92985
	P70434
	NM_001572; NM_004029; NM_004030; NM_004031
	NM_001252600; NM_001252601; NM_016850
	NP_001563; NP_004020; NP_004022
	NP_001239529; NP_001239530; NP_058546
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

^ ^a ^b ^c ENSG00000185507 GRCh38: Ensembl release 89: ENSG00000276561, ENSG00000185507 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025498 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] ENSG00000185507 GRCh38: Ensembl release 89: ENSG00000276561, ENSG00000185507 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025498 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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