IRS4

IRS4
Identifiers
Aliases	IRS4, IRS-4, PY160, insulin receptor substrate 4, CHNG9
External IDs	OMIM: 300904; MGI: 1338009; HomoloGene: 136777; GeneCards: IRS4; OMA:IRS4 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	108,736,563 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	140,508,259 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; ovary; ; left ovary; ; right ovary; ; gastric mucosa; ; hypothalamus; ; body of uterus; ; right lobe of thyroid gland; ; cervix;
	Top expressed in
	median eminence; ; arcuate nucleus; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; substantia nigra; ; gastrula; ; mammillary body; ; lateral hypothalamus; ; nucleus of stria terminalis; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol 3-kinase binding; protein binding; signal transducer activity; insulin receptor binding;
Cellular component	cytosol; membrane; plasma membrane;
Biological process	insulin receptor signaling pathway; regulation of lipid metabolic process; signal transduction; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	8471
	16370
	ENSG00000133124
	ENSMUSG00000054667
	O14654
	Q9Z0Y7
	NM_003604; NM_001379150
	NM_010572
	NP_003595; NP_001366079
	NP_034702
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.^[5]^[6]^[7]

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133124 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054667 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE (Sep 1997). "A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family". J Biol Chem. 272 (34): 21403–7. doi:10.1074/jbc.272.34.21403. PMID 9261155.
^ Fantin VR, Sparling JD, Slot JW, Keller SR, Lienhard GE, Lavan BE (May 1998). "Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells". J Biol Chem. 273 (17): 10726–32. doi:10.1074/jbc.273.17.10726. PMID 9553137.
^ ^a ^b "Entrez Gene: IRS4 insulin receptor substrate 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133124 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054667 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9261155-5] Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE (Sep 1997). "A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family". J Biol Chem. 272 (34): 21403–7. doi:10.1074/jbc.272.34.21403. PMID 9261155.

[pmid9553137-6] Fantin VR, Sparling JD, Slot JW, Keller SR, Lienhard GE, Lavan BE (May 1998). "Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells". J Biol Chem. 273 (17): 10726–32. doi:10.1074/jbc.273.17.10726. PMID 9553137.

[entrez-7] "Entrez Gene: IRS4 insulin receptor substrate 4".

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