IRX2

IRX2
Identifiers
Aliases	IRX2, IRXA2, iroquois homeobox 2
External IDs	OMIM: 606198; MGI: 1197526; HomoloGene: 56490; GeneCards: IRX2; OMA:IRX2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	2,751,677 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	72,782,317 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; lower lobe of lung; ; lactiferous duct; ; parotid gland; ; skin of thigh; ; pons; ; renal medulla; ; bronchial epithelial cell; ; nipple; ; buccal mucosa cell;
	Top expressed in
	pretectal area; ; otic placode; ; lip; ; otic vesicle; ; saccule; ; lacrimal gland; ; epidermis; ; zone of skin; ; skin of abdomen; ; skin of back;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	specification of loop of Henle identity; metanephros development; regulation of transcription, DNA-templated; proximal/distal pattern formation involved in metanephric nephron development; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	153572
	16372
	ENSG00000170561
	ENSMUSG00000001504
	Q9BZI1
	P81066
	NM_001134222; NM_033267
	NM_010574
	NP_001127694; NP_150366
	NP_034704
	Wikidata
View/Edit Human	View/Edit Mouse

Iroquois-class homeodomain protein IRX-2, also known as Iroquois homeobox protein 2, is a protein that in humans is encoded by the IRX2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170561 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001504 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: iroquois homeobox 2".
^ Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T (2001). "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes". Cytogenet. Cell Genet. 92 (3–4): 320–5. doi:10.1159/000056921. PMID 11435706. S2CID 46509502.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170561 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001504 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: iroquois homeobox 2".

[pmid11435706-6] Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T (2001). "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes". Cytogenet. Cell Genet. 92 (3–4): 320–5. doi:10.1159/000056921. PMID 11435706. S2CID 46509502.

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