IRX4

IRX4
Identifiers
Aliases	IRX4, IRXA3, iroquois homeobox 4
External IDs	OMIM: 606199; MGI: 1355275; HomoloGene: 9485; GeneCards: IRX4; OMA:IRX4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	1,887,236 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	73,417,727 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; apex of heart; ; skin of leg; ; hair follicle; ; gonad; ; left ventricle; ; minor salivary glands; ; vagina; ; right ventricle; ; epithelium of lactiferous gland;
	Top expressed in
	lip; ; ventricle; ; atrioventricular canal; ; endocardial cushion; ; myocardium of ventricle; ; cardiac muscles; ; right ventricle; ; atrioventricular valve; ; primordial ventricle; ; upper lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	heart development; regulation of transcription, DNA-templated; establishment of animal organ orientation; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	50805
	50916
	ENSG00000113430
	ENSMUSG00000021604
	P78413
	Q9QY61
	NM_016358; NM_001278632; NM_001278633; NM_001278634; NM_001278635
	NM_018885
	NP_001265561; NP_001265562; NP_001265563; NP_001265564; NP_057442
	NP_061373
	Wikidata
View/Edit Human	View/Edit Mouse

Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113430 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021604 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: iroquois homeobox 4".
^ Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand". Dev. Biol. 217 (2): 266–77. doi:10.1006/dbio.1999.9548. PMID 10625552.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113430 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021604 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: iroquois homeobox 4".

[pmid10625552-6] Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand". Dev. Biol. 217 (2): 266–77. doi:10.1006/dbio.1999.9548. PMID 10625552.

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