ITPA

ITPA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CAR, 2I5D, 2J4E, 4F95
Identifiers
Aliases	ITPA, C20orf37, HLC14-06-P, dJ794I6.3, My049, ITPase, NTPase, inosine triphosphatase, DEE35
External IDs	OMIM: 147520; MGI: 96622; HomoloGene: 6289; GeneCards: ITPA; OMA:ITPA - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 3,208,868 bp[1] End 3,223,870 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.24 cM Start 130,509,530 bp[2] End 130,523,534 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland mucosa of transverse colon right adrenal cortex right uterine tube left adrenal gland left adrenal cortex mucosa of esophagus granulocyte skin of leg Top expressed in embryo embryo ventricular zone endocardial cushion epiblast primitive streak morula ganglionic eminence neural tube otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding dITP diphosphatase activity XTP diphosphatase activity ITP diphosphatase activity hydrolase activity metal ion binding nucleotide diphosphatase activity NADH pyrophosphatase activity nucleoside-triphosphate diphosphatase activity identical protein binding Cellular component cytoplasm cytosol Biological process ITP catabolic process nucleotide metabolic process chromosome organization nucleoside triphosphate catabolic process purine nucleotide catabolic process deoxyribonucleoside triphosphate catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3704 16434 Ensembl ENSG00000125877 ENSMUSG00000074797 UniProt Q9BY32 Q9D892 RefSeq (mRNA) NM_001267623 NM_033453 NM_181493 NM_001324236 NM_001324237 NM_001324238 NM_001324240 NM_001351739 NM_025922 NM_001362648 RefSeq (protein) NP_001254552 NP_001311165 NP_001311166 NP_001311167 NP_001311169 NP_258412 NP_852470 NP_001338668 NP_080198 NP_001349577 Location (UCSC) Chr 20: 3.21 – 3.22 Mb Chr 2: 130.51 – 130.52 Mb PubMed search [3] [4]
Wikidata
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Inosine triphosphate pyrophosphatase is an enzyme that in humans is encoded by the ITPA gene,^[5][6] by the rdgB gene in bacteria E.coli^[7] and the HAM1 gene in yeast S. cerevisiae;^[8] the protein is also encoded by some RNA viruses of the Potyviridae family.^[9] Two transcript variants encoding two different isoforms have been found for this gene. Also, at least two other transcript variants have been identified which are probably regulatory rather than protein-coding.^{[citation needed]}