ITPKA

ITPKA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W2C, 1W2D, 1W2F, 4UPU
Identifiers
Aliases	ITPKA, IP3-3KA, IP3KA, inositol-trisphosphate 3-kinase A
External IDs	OMIM: 147521; MGI: 1333822; HomoloGene: 1671; GeneCards: ITPKA; OMA:ITPKA - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	41,503,551 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	119,581,744 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right frontal lobe; ; Brodmann area 9; ; prefrontal cortex; ; middle temporal gyrus; ; caudate nucleus; ; putamen; ; cingulate gyrus; ; anterior cingulate cortex; ; nucleus accumbens;
	Top expressed in
	Region I of hippocampus proper; ; hippocampus proper; ; primary visual cortex; ; prefrontal cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; dorsal striatum; ; temporal lobe; ; nucleus accumbens; ; amygdala;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calmodulin-dependent protein kinase activity; transferase activity; nucleotide binding; inositol-1,4,5-trisphosphate 3-kinase activity; ATP binding; calmodulin binding; kinase activity;
Cellular component	cytosol; dendritic spine;
Biological process	dendritic spine maintenance; protein phosphorylation; inositol phosphate metabolic process; positive regulation of dendritic spine morphogenesis; actin cytoskeleton organization; inositol metabolic process; phosphorylation; signal transduction; regulation of synaptic plasticity; inositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	3706
	228550
	ENSG00000137825
	ENSMUSG00000027296
	P23677
	Q8R071
	NM_002220
	NM_146125
	NP_002211
	NP_666237
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol-trisphosphate 3-kinase A is an enzyme that in humans is encoded by the ITPKA gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137825 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027296 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Erneux C, Roeckel N, Takazawa K, Mailleux P, Vassart G, Mattei MG (October 1992). "Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization". Genomics. 14 (2): 546–7. doi:10.1016/S0888-7543(05)80265-4. PMID 1330886.
^ Takazawa K, Perret J, Dumont JE, Erneux C (December 1990). "Human brain inositol 1,4,5-trisphosphate 3-kinase cDNA sequence". Nucleic Acids Research. 18 (23): 7141. doi:10.1093/nar/18.23.7141. PMC 332787. PMID 2175886.
^ "Entrez Gene: ITPKA inositol 1,4,5-trisphosphate 3-kinase A".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137825 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027296 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1330886-5] Erneux C, Roeckel N, Takazawa K, Mailleux P, Vassart G, Mattei MG (October 1992). "Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization". Genomics. 14 (2): 546–7. doi:10.1016/S0888-7543(05)80265-4. PMID 1330886.

[pmid2175886-6] Takazawa K, Perret J, Dumont JE, Erneux C (December 1990). "Human brain inositol 1,4,5-trisphosphate 3-kinase cDNA sequence". Nucleic Acids Research. 18 (23): 7141. doi:10.1093/nar/18.23.7141. PMC 332787. PMID 2175886.

[entrez-7] "Entrez Gene: ITPKA inositol 1,4,5-trisphosphate 3-kinase A".

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