ITPR3

ITPR3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JRR
Identifiers
Aliases	ITPR3, IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3
External IDs	OMIM: 147267; MGI: 96624; HomoloGene: 1675; GeneCards: ITPR3; OMA:ITPR3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,696,574 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	27,341,197 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; pylorus; ; skin of arm; ; trigeminal ganglion; ; sural nerve; ; skin of thigh; ; olfactory bulb; ; left lobe of thyroid gland; ; spinal ganglia; ; right lobe of thyroid gland;
	Top expressed in
	molar; ; pyloric antrum; ; epithelium of stomach; ; skin of external ear; ; mucous cell of stomach; ; lip; ; epithelium of small intestine; ; sciatic nerve; ; rib; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel activity; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; ion channel activity; protein binding; inositol 1,3,4,5 tetrakisphosphate binding; calcium-release channel activity; inositol hexakisphosphate binding; inositol 1,4,5 trisphosphate binding; calcium ion binding; phosphatidylinositol binding;
Cellular component	cytoplasm; integral component of membrane; endoplasmic reticulum membrane; membrane; receptor complex; plasma membrane; apical part of cell; integral component of plasma membrane; nucleoplasm; nucleolus; platelet dense tubular network membrane; endoplasmic reticulum; brush border; nucleus; nuclear outer membrane; myelin sheath; neuronal cell body; sarcoplasmic reticulum; cytoplasmic vesicle membrane; secretory granule membrane;
Biological process	sensory perception of umami taste; calcium ion transport into cytosol; regulation of cardiac conduction; regulation of insulin secretion; memory; ion transport; platelet activation; response to calcium ion; sensory perception of bitter taste; calcium ion transmembrane transport; transmembrane transport; sensory perception of sweet taste; inositol phosphate-mediated signaling; calcium ion transport; long-term potentiation; G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; protein homooligomerization; protein heterooligomerization; release of sequestered calcium ion into cytosol; transport;
	Sources:Amigo / QuickGO
Orthologs
	3710
	16440
	ENSG00000096433
	ENSMUSG00000042644
	Q14573
	P70227
	NM_002224
	NM_080553
	NP_002215
	NP_542120
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene.^[5] The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000096433 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042644 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: inositol 1".
^ Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels. 2 (1): 9–22. PMID 8081734.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000096433 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042644 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: inositol 1".

[pmid8081734-6] Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels. 2 (1): 9–22. PMID 8081734.

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