Ibutilide

Ibutilide
Clinical data
Trade namesCorvert
AHFS/Drugs.comMonograph
MedlinePlusa601248
Pregnancy
category
  • C
Routes of
administration
Intravenous
ATC code
Pharmacokinetic data
BioavailabilityN/A
Protein binding40%
MetabolismHepatic oxidation
Elimination half-life6 hours (2-12 hours)
ExcretionRenal (82%), fecal
Identifiers
  • N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H36N2O3S
Molar mass384.58 g·mol−1
3D model (JSmol)
  • O=S(=O)(Nc1ccc(cc1)C(O)CCCN(CC)CCCCCCC)C
  • InChI=1S/C20H36N2O3S/c1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25/h12-15,20-21,23H,4-11,16-17H2,1-3H3 checkY
  • Key:ALOBUEHUHMBRLE-UHFFFAOYSA-N checkY
  (verify)

Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. Because of its Class III antiarrhythmic activity, there should not be concomitant administration of Class Ia and Class III agents.

Ibutilide is marketed as Corvert by Pfizer. Administration resulted in successful heart rhythm control in 31–44% of patients within 90 minutes, with sustained polymorphic ventricular tachycardia in 0.9–2.5% of patients. It appears to show better results in atrial flutter as compared to atrial fibrillation.[1]

  1. ^ Kowey PR, Stoenescu ML (2005). "Selection of drugs in pursuit of a rhythm control strategy". Progress in Cardiovascular Diseases. 48 (2): 139–45. doi:10.1016/j.pcad.2005.06.009. PMID 16253653.