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| Combination of | |
|---|---|
| Imipenem | Carbapenem antibiotic |
| Cilastatin | Dehydropeptidase inhibitor |
| Clinical data | |
| Trade names | Primaxin, Tienam, Cilasafe, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a605011 |
| Routes of administration | IV, IM |
| ATC code | |
| Legal status | |
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| Identifiers | |
| CAS Number | |
| PubChem CID | |
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| CompTox Dashboard (EPA) | |
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Imipenem/cilastatin, sold under the brand name Primaxin among others, is an antibiotic useful for the treatment of a number of bacterial infections.[1] It is made from a combination of imipenem and cilastatin.[1] Specifically it is used for pneumonia, sepsis, endocarditis, joint infections, intra-abdominal infections, and urinary tract infections.[1] It is given by injection into a vein or muscle.[1]
Common side effects include nausea, diarrhea, and pain at the site of injection.[1] Other side effects may include Clostridium difficile diarrhea and allergic reactions including anaphylaxis.[1] It is unclear if use during pregnancy is safe for the baby.[2] Imipenem is in the carbapenem family of medications and works by interfering with the bacteria's cell wall.[1] Cilastatin blocks the activity of dehydropeptidase I which prevents the breakdown of imipenem.[1]
Imipenem/cilastatin was first sold in 1987.[3] It is on the World Health Organization's List of Essential Medicines.[4]
- ^ a b c d e f g h "Imipenem and Cilastatin". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
- ^ "Cilastatin / imipenem Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 20 December 2016. Retrieved 10 December 2016.
- ^ Oxford Handbook of Infectious Diseases and Microbiology. OUP Oxford. 2009. p. 56. ISBN 9780191039621. Archived from the original on 2015-11-24.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.