Indian hedgehog (protein)

IHH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3K7G, 3K7H, 3K7I, 3K7J, 3N1F, 3N1M, 3N1O, 3N1P
Identifiers
Aliases	IHH, BDA1, HHG2, indian hedgehog, Indian hedgehog signaling molecule
External IDs	OMIM: 600726; MGI: 96533; HomoloGene: 22586; GeneCards: IHH; OMA:IHH - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	219,060,921 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,990,831 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; testicle; ; gonad; ; mucosa of ileum; ; tibia; ; rectum; ; mucosa of sigmoid colon; ; duodenum; ; jejunal mucosa; ; pylorus;
	Top expressed in
	forearm; ; humerus; ; tibia; ; finger; ; epithelium of stomach; ; epiphyseal plate; ; yolk sac; ; left colon; ; ulna; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; peptidase activity; hydrolase activity; patched binding; protein binding;
Cellular component	membrane; plasma membrane; extracellular region; extracellular space; extracellular matrix;
Biological process	response to estradiol; maternal process involved in female pregnancy; positive regulation of epithelial cell proliferation; cell-cell signaling; negative regulation of apoptotic process; proteolysis; multicellular organism development; intein-mediated protein splicing; smoothened signaling pathway; positive regulation of transcription by RNA polymerase II; skeletal system development; ossification; branching involved in blood vessel morphogenesis; osteoblast differentiation; in utero embryonic development; cell fate specification; morphogenesis of a branching structure; vasculature development; heart looping; positive regulation of mesenchymal cell proliferation; epithelial cell morphogenesis; retinal pigment epithelium development; chondrocyte differentiation involved in endochondral bone morphogenesis; proteoglycan metabolic process; pattern specification process; positive regulation of cell population proliferation; embryonic pattern specification; cell differentiation; vitelline membrane formation; pancreas development; positive regulation of collagen biosynthetic process; negative regulation of T cell differentiation in thymus; negative regulation of immature T cell proliferation in thymus; positive regulation of T cell differentiation in thymus; multicellular organism growth; chondrocyte proliferation; regulation of growth; embryonic digit morphogenesis; camera-type eye development; bone resorption; negative regulation of cell differentiation; positive regulation of smoothened signaling pathway; positive regulation of alpha-beta T cell differentiation; negative regulation of alpha-beta T cell differentiation; negative regulation of eye pigmentation; cell maturation; embryonic digestive tract morphogenesis; embryonic camera-type eye morphogenesis; neuron development; smooth muscle tissue development; cartilage development; camera-type eye photoreceptor cell fate commitment; head morphogenesis; somite development; embryonic skeletal joint development; epithelial cell-cell adhesion; response to mechanical stimulus; liver regeneration; regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	3549
	16147
	ENSG00000163501
	ENSMUSG00000006538
	Q14623
	P97812
	NM_002181
	NM_010544; NM_001313683
	NP_002172
	NP_001300612; NP_034674
	Wikidata
View/Edit Human	View/Edit Mouse

Indian hedgehog homolog (Drosophila), also known as IHH, is a protein which in humans is encoded by the IHH gene.^[5]^[6]^[7] This cell signaling protein is in the hedgehog signaling pathway. The several mammalian variants of the Drosophila hedgehog gene (which was the first named) have been named after the various species of hedgehog; the Indian hedgehog is honored by this one. The gene is not specific to Indian hedgehogs.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163501 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006538 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IHH Indian hedgehog homolog (Drosophila)".
^ Marigo V, Roberts DJ, Lee SM, Tsukurov O, Levi T, Gastier JM, Epstein DJ, Gilbert DJ, Copeland NG, Seidman CE (July 1995). "Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog". Genomics. 28 (1): 44–51. doi:10.1006/geno.1995.1104. PMID 7590746.
^ van den Brink GR, Bleuming SA, Hardwick JC, Schepman BL, Offerhaus GJ, Keller JJ, Nielsen C, Gaffield W, van Deventer SJ, Roberts DJ, Peppelenbosch MP (March 2004). "Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation". Nat. Genet. 36 (3): 277–82. doi:10.1038/ng1304. PMID 14770182.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163501 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006538 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IHH Indian hedgehog homolog (Drosophila)".

[pmid7590746-6] Marigo V, Roberts DJ, Lee SM, Tsukurov O, Levi T, Gastier JM, Epstein DJ, Gilbert DJ, Copeland NG, Seidman CE (July 1995). "Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog". Genomics. 28 (1): 44–51. doi:10.1006/geno.1995.1104. PMID 7590746.

[pmid14770182-7] van den Brink GR, Bleuming SA, Hardwick JC, Schepman BL, Offerhaus GJ, Keller JJ, Nielsen C, Gaffield W, van Deventer SJ, Roberts DJ, Peppelenbosch MP (March 2004). "Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation". Nat. Genet. 36 (3): 277–82. doi:10.1038/ng1304. PMID 14770182.

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