Based on the median lethal dose value in mice, the venom of the inland taipan is by far the most toxic of any snake – much more so than even that of sea snakes[11][12][13] – and it has the most toxic venom of any reptile when tested on human heart cell culture.[14][15][16] The inland taipan is a specialist hunter of mammals, so its venom is specially adapted to kill warm-blooded species.[17] One bite possesses enough lethality to kill more than an estimated 100 fully grown humans.[18] It is an extremely fast and agile snake that can strike instantly with extreme accuracy,[19] often striking multiple times in the same attack,[20] and it envenomates in almost every case.[21]
Although the most venomous and a capable striker, in contrast to the coastal taipan, which many experts cite as an extremely dangerous snake due to its behaviour when it encounters humans,[22][23][24] the inland taipan is usually quite a shy and reclusive snake, with a placid disposition,[25] and prefers to escape from trouble.[26] However, it will defend itself and strike if provoked,[27] mishandled,[28] or prevented from escaping.[29] Because it lives in such remote locations, the inland taipan seldom comes in contact with people;[30] therefore it is not considered the deadliest snake in the world overall, especially in terms of disposition and human deaths per year.[31] The word "fierce" from its alternative name describes its venom, not its temperament.[32]
^Fohlman, J. (1979). "Comparison of two highly toxic Australian snake venoms: The taipan (Oxyuranus s. scutellatus) and the fierce snake (Parademansia microlepidotus)". Toxicon. 17 (2): 170–2. doi:10.1016/0041-0101(79)90296-4. PMID442105.
^White, Julian (November 1991). Oxyuranus microlepidotus. "Neurotoxic paralysis usually takes 2-4 hours to become clinically detectable. Coagulopathy however may become well established within 30 minutes of a bite" International Programme on Chemical Safety. Retrieved 8 November 2013.
^Pearn, John; Winkel, Kenneth D. (December 2006). "Toxinology in Australia's colonial era: A chronology and perspective of human envenomation in 19th century Australia". Toxicon. 48 (7): 726–737. doi:10.1016/j.toxicon.2006.07.027. PMID16996551.
Department of Wildlife Ecology and Conservation. Frequently Asked Questions About Venomous Snakes. "A comparative study found that the snake venom that is most toxic to mice (of the species tested) is that of the Inland Taipan (Oxyuranus microlepidotus), found in Australia". University of Florida. Retrieved 5 November 2013.
Hodgson WC, Dal Belo CA, Rowan EG (2007). "The neuromuscular activity of paradoxin: a presynaptic neurotoxin from the venom of the inland taipan (Oxyuranus microlepidotus)". Neuropharmacology. 52 (5): 1229–36. doi:10.1016/j.neuropharm.2007.01.002. PMID17313963. S2CID19532337. The inland taipan is the world's most venomous snake
Bell, Karen L; Sutherland, Struan K; Hodgson, Wayne C (1998). "Some pharmacological studies of venom from the inland taipan (Oxyuranus microlepidotus)". Toxicon. 36 (1): 63–74. doi:10.1016/S0041-0101(97)00060-3. PMID9604283. The Inland Taipan is believed to have the most toxic venom in the world (Sutherland, 1994)
Journal of Herpetology Vol.17 no.1 (1983) Ecology of Highly Venoumous Snakes: the Australian Genus Oxyuranus. "..the number of mouse LD50 doses per bite is much higher for Oxyuranus microlepidotus (218,000 mice)...than for any other snakes, including sea snakes, investigated to date (Broad, Sutherland and Coulter, 1979)." (page 1) University of Sydney. Retrieved 8 November 2013.
BBC Nature Wildlife. Inland Taipan page. "Australia's inland taipan is considered to be the most venomous snake in the world". BBC. Retrieved 15 October 2013.
Cecilie Beatson (29 November 2011). Animal Species: Inland Taipan "The venom of the Inland Taipan is extremely potent and is rated as the most toxic of all snake venoms in LD50 tests on mice". Australian Museum. Retrieved 14 October 2013.
Fry, Brian site admin (10 April 2005) Most VenomousArchived 2014-10-17 at the Wayback Machine, Question: " ...I was talking to another herpatolagist and he said the hook nosed sea snake was the most venomous of all" Fry Answers: "The hook nosed myth was due to a fundamental error in a book called 'Snakes in question'. In there, all the toxicity testing results were lumped in together, regardless of the mode of testing (e.g. subcutaneous vs. intramuscular vs intravenous vs intraperitoneal). As the mode can influence the relative number, venoms can only be compared within a mode. Otherwise, its apples and rocks." Venomdoc forums. Retrieved 25 February 2015.
kingsnake.com September Guest Chatter (16 September 2006).Q&A with Dr. Bryan Grieg Fry, Deputy Director, Australian Venom Research Unit, University of MelbourneArchived 2012-10-15 at the Wayback Machine. "Q: In retrospect to the LD50 charts, what do you personally feel is the hottest snake, in regards to potency, defensiveness, means of injection, etc.? A: It is the inland taipan (Oxyuranus microlepidotus). Not, as is popularised, any of the sea snakes." connectedbypets.com. Retrieved 14 October 2013.
Garden of Eden Exotics (2 May 2012) Dr. Bryan Grieg Fry – Interview "...The inland taipan (Oxyuranus microlepidotus) is far and away the most toxic, much more so than even sea snakes." nyexotics.blogspot.com. Retrieved 14 October 2013.
^Fry, BryanArchived 2014-04-19 at the Wayback Machine (8 February 2005) Most VenomousArchived 2014-10-17 at the Wayback Machine,"Q;I was wondering what snakes venom is the most potent to humans A:Drop for drop it is the inland taipan (Oxyuranus microlepidotus), which has a venom more toxic than any other land snake or even the sea snakes." venomdoc.com Forums, Retrieved 17 April 2014.
^* Journal of Herpetology Vol.17 no.1 (1983) Ecology of Highly Venoumous Snakes: the Australian Genus Oxyuranus. "..the number of mouse LD50 doses per bite is much higher for Oxyuranus microlepidotus (218,000 mice)...than for any other snakes, including sea snakes, investigated to date (Broad, Sutherland and Coulter, 1979)." (page 1) University of Sydney. Retrieved 8 November 2013.
Martin, Stella (January 2004). Newsletter No. 80. "It has been calculated that there is enough venom in just one bite of an Inland taipan to kill more than 100 men of average size." Environmental Protection Agency (Queensland). Retrieved 18 October 2013.
Clinical Toxinology Resources. Snakebite Protocols – Oxyuranus microlepidotusArchived 10 August 2018 at the Wayback Machine. "Signs and Symptoms of Envenomation:E. Fang Marks: The snake strikes with extraordinary speed and accuracy, often snapping its jaws fiercely several times which can result in multiple punctures in the same attack.", "Special Considerations:A. Multiple Bites: The Inland Taipan is an extremely fast and agile snake which can strike instantly with extreme accuracy. It is possible for a Taipan to deliver more than one bite in a single attack." University of Adelaide. Retrieved 18 October 2013.
Clinical Toxinology Resources. Snakebite Protocols – Oxyuranus microlepidotusArchived 10 August 2018 at the Wayback Machine. "Signs and Symptoms of Envenomation:E. Fang Marks: The snake strikes with extraordinary speed and accuracy, often snapping its jaws fiercely several times which can result in multiple punctures in the same attack.", "Special Considerations:A. Multiple Bites: The Inland Taipan is an extremely fast and agile snake which can strike instantly with extreme accuracy. It is possible for a Taipan to deliver more than one bite in a single attack." University of Adelaide. Retrieved 18 October 2013.
^"Coastal Taipan". Archived from the original on 2 February 2021. Retrieved 21 October 2013.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
^* Cecilie Beatson (29 November 2011). Animal Species: Inland Taipan "The venom of the Inland Taipan is extremely potent and is rated as the most toxic of all snake venoms in LD50 tests on mice". Australian Museum. Retrieved 14 October 2013.
Cecilie Beatson (29 November 2011). Animal Species: Inland Taipan "The venom of the Inland Taipan is extremely potent and is rated as the most toxic of all snake venoms in LD50 tests on mice". Australian Museum. Retrieved 14 October 2013.
National Geographic Channel, (Dangerous Encounters with Brady Barr), video clip. Deadliest Snakes / Inland TaipanArchived 12 April 2017 at the Wayback Machine "in Deadliest Snakes, Brady approaches seven of the world's most dangerous and venomous snakes to determine which snake is the deadliest. He will scientifically investigate each species of snake by grading them on five basic criteria: size, volume and toxicity of venom, personality, and number of human deaths." Reptile Gardens (video host). Retrieved 6 November 2013.