Inner nuclear membrane protein

Inner nuclear membrane proteins structure. Amino-termini (N) and carboxy-termini (C) are indicated in red. Adapted from Holmer and Worman (2001)[1]

Inner nuclear membrane proteins (INM proteins) are membrane proteins that are embedded in or associated with the inner membrane of the nuclear envelope. There are about 60 INM proteins, most of which are poorly characterized with respect to structure and function.[2] Among the few well-characterized INM proteins are lamin B receptor (LBR), lamina-associated polypeptide 1 (LAP1), lamina-associated polypeptide-2 (LAP2), emerin and MAN1.

  1. ^ Holmer, L.; Worman, H.J. (2001). "Inner nuclear membrane proteins: Functions and targeting". Cellular and Molecular Life Sciences. 58 (12): 1741–7. doi:10.1007/PL00000813. PMC 11337314. PMID 11766875. S2CID 20902309.
  2. ^ Méndez-López, Iván; Worman, Howard J. (2012). "Inner nuclear membrane proteins: Impact on human disease". Chromosoma. 121 (2): 153–67. doi:10.1007/s00412-012-0360-2. PMID 22307332. S2CID 17006310.