Inositol trisphosphate receptor

See also: Ryanodine-Inositol 1,4,5-triphosphate receptor calcium channels
inositol 1,4,5-trisphosphate receptor, type 1[1]
Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor
Identifiers
SymbolITPR1
NCBI gene3708
HGNC6180
OMIM147265
RefSeqNM_002222
UniProtQ14643
Other data
LocusChr. 3 p26.1
Search for
StructuresSwiss-model
DomainsInterPro
inositol 1,4,5-trisphosphate receptor, type 2
Identifiers
SymbolITPR2
NCBI gene3709
HGNCstructure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor 6181 Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor 6181
OMIM600144
RefSeqNM_002223
UniProtQ14571
Other data
LocusChr. 12 p11.23
Search for
StructuresSwiss-model
DomainsInterPro
inositol 1,4,5-trisphosphate receptor, type 3
Single-particle cryo-EM structure of the IP3-bound resting state.
Identifiers
SymbolITPR3
NCBI gene3710
HGNC6182
OMIM147267
RefSeqNM_002224
UniProtQ14573
Other data
LocusChr. 6 p21.31
Search for
StructuresSwiss-model
DomainsInterPro

Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca2+ channel activated by inositol trisphosphate (InsP3). InsP3R is very diverse among organisms, and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory.[2] Inositol triphosphate receptor represents a dominant second messenger leading to the release of Ca2+ from intracellular store sites. There is strong evidence suggesting that the InsP3R plays an important role in the conversion of external stimuli to intracellular Ca2+ signals characterized by complex patterns relative to both space and time, such as Ca2+ waves and oscillations.[3]

  1. ^ Bosanac I, Yamazaki H, Matsu-Ura T, Michikawa T, Mikoshiba K, Ikura M (January 2005). "Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor". Molecular Cell. 17 (2): 193–203. doi:10.1016/j.molcel.2004.11.047. PMID 15664189.
  2. ^ Bosanac I, Alattia JR, Mal TK, Chan J, Talarico S, Tong FK, et al. (December 2002). "Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand". Nature. 420 (6916): 696–700. Bibcode:2002Natur.420..696B. doi:10.1038/nature01268. PMID 12442173. S2CID 4422308.
  3. ^ Yoshida Y, Imai S (June 1997). "Structure and function of inositol 1,4,5-trisphosphate receptor". Japanese Journal of Pharmacology. 74 (2): 125–137. doi:10.1254/jjp.74.125. PMID 9243320.