Insulin-like growth factor 1 receptor

IGF1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU, 4D2R, 4XSS, 5HZN
Identifiers
Aliases	IGF1R, CD221, IGFIR, IGFR, JTK13, insulin like growth factor 1 receptor, Insulin-like growth factor 1，IGF-1R
External IDs	OMIM: 147370; MGI: 96433; HomoloGene: 30997; GeneCards: IGF1R; OMA:IGF1R - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.3 Start 98,648,539 bp[1] End 98,964,530 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 C|7 37.27 cM Start 67,602,575 bp[2] End 67,883,416 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caput epididymis corpus epididymis renal medulla tail of epididymis saphenous vein lactiferous duct sural nerve bronchial epithelial cell retinal pigment epithelium stromal cell of endometrium Top expressed in molar transitional epithelium of urinary bladder ciliary body retinal pigment epithelium conjunctival fornix seminal vesicula choroid plexus of fourth ventricle Rostral migratory stream vestibular membrane of cochlear duct pineal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity insulin-like growth factor binding insulin receptor binding insulin binding kinase activity phosphatidylinositol 3-kinase binding insulin-like growth factor-activated receptor activity protein binding identical protein binding transmembrane receptor protein tyrosine kinase activity insulin receptor substrate binding protein tyrosine kinase activity ATP binding insulin-like growth factor I binding insulin-activated receptor activity Cellular component integral component of membrane membrane intracellular membrane-bounded organelle receptor complex plasma membrane integral component of plasma membrane alphav-beta3 integrin-IGF-1-IGF1R complex insulin receptor complex axon Biological process insulin receptor signaling pathway insulin-like growth factor receptor signaling pathway phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell migration negative regulation of apoptotic process protein tetramerization positive regulation of DNA replication protein phosphorylation regulation of JNK cascade immune response positive regulation of cell population proliferation peptidyl-tyrosine autophosphorylation protein autophosphorylation phosphatidylinositol 3-kinase signaling phosphatidylinositol-mediated signaling signal transduction positive regulation of phosphatidylinositol 3-kinase signaling glucose homeostasis positive regulation of protein-containing complex disassembly positive regulation of MAPK cascade anatomical structure development positive regulation of protein kinase B signaling cellular response to glucose stimulus dendritic spine maintenance amyloid-beta clearance positive regulation of cold-induced thermogenesis cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3480 16001 Ensembl ENSG00000140443 ENSMUSG00000005533 UniProt P08069 Q60751 RefSeq (mRNA) NM_000875 NM_001291858 NM_152452 NM_010513 RefSeq (protein) NP_000866 NP_001278787 NP_034643 Location (UCSC) Chr 15: 98.65 – 98.96 Mb Chr 7: 67.6 – 67.88 Mb PubMed search [3] [4]
Wikidata
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The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults – meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass. This testifies to the strong growth-promoting effect of this receptor.