Insulin-like growth factor 2 receptor

IGF2R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E6F, 1GP0, 1GP3, 1GQB, 1JPL, 1JWG, 1LF8, 2CNJ, 2V5N, 2V5O, 2V5P, 2L29, 2L2A, 2M68, 5IEI, 2M6T
Identifiers
Aliases	IGF2R, CD222, CIMPR, M6P-R, MPR1, MPRI, M6P/MPR 300, CI-M6PR, MPR300, insulin like growth factor 2 receptor
External IDs	OMIM: 147280; MGI: 96435; HomoloGene: 676; GeneCards: IGF2R; OMA:IGF2R - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 159,969,082 bp[1] End 160,113,507 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 8.64 cM Start 12,901,293 bp[2] End 12,988,551 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium gastrocnemius muscle granulocyte blood muscle of thigh tibialis anterior muscle monocyte spleen upper lobe of left lung right adrenal cortex Top expressed in atrium umbilical cord atrioventricular valve internal carotid artery endocardial cushion lacrimal gland epithelium of small intestine human fetus left lung lobe Ileal epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function retinoic acid binding insulin-like growth factor binding G protein-coupled receptor activity transporter activity phosphoprotein binding insulin-like growth factor-activated receptor activity insulin-like growth factor II binding mannose binding identical protein binding enzyme binding G-protein alpha-subunit binding protein binding kringle domain binding signaling receptor activity Cellular component cytoplasm integral component of membrane endosome late endosome membrane focal adhesion clathrin coat endocytic vesicle integral component of plasma membrane cell surface lysosomal membrane trans-Golgi network early endosome nuclear envelope lumen perinuclear region of cytoplasm trans-Golgi network transport vesicle lysosome extracellular exosome nucleus trans-Golgi network membrane transport vesicle extracellular space Golgi apparatus plasma membrane clathrin-coated vesicle membrane secretory granule membrane clathrin-coated vesicle Biological process regulation of apoptotic process G protein-coupled receptor signaling pathway response to retinoic acid post-embryonic development receptor-mediated endocytosis animal organ regeneration spermatogenesis positive regulation of apoptotic process liver development signal transduction insulin-like growth factor receptor signaling pathway neutrophil degranulation membrane organization transport post-Golgi vesicle-mediated transport lysosomal transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3482 16004 Ensembl ENSG00000197081 ENSMUSG00000023830 UniProt P11717 Q07113 RefSeq (mRNA) NM_000876 NM_010515 RefSeq (protein) NP_000867 NP_034645 Location (UCSC) Chr 6: 159.97 – 160.11 Mb Chr 17: 12.9 – 12.99 Mb PubMed search [3] [4]
Wikidata
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Insulin-like growth factor 2 receptor (IGF2R), also called the cation-independent mannose-6-phosphate receptor (CI-MPR) is a protein that in humans is encoded by the IGF2R gene.^[5][6] IGF2R is a multifunctional protein receptor that binds insulin-like growth factor 2 (IGF2) at the cell surface and mannose-6-phosphate (M6P)-tagged proteins in the trans-Golgi network.^[6]