Insulin receptor substrate 1

IRS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IRS, 1K3A, 1QQG, 2Z8C
Identifiers
Aliases	IRS1, HIRS-1, insulin receptor substrate 1
External IDs	OMIM: 147545; MGI: 99454; HomoloGene: 4049; GeneCards: IRS1; OMA:IRS1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q36.3 Start 226,731,312 bp[1] End 226,799,820 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C5|1 42.0 cM Start 82,210,822 bp[2] End 82,269,137 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis tibia epithelium of lactiferous gland lactiferous duct cartilage tissue vastus lateralis muscle decidua biceps brachii stromal cell of endometrium mucosa of urinary bladder Top expressed in calvaria pineal gland triceps brachii muscle vastus lateralis muscle sternocleidomastoid muscle temporal muscle body of femur digastric muscle ankle vestibular sensory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function insulin-like growth factor receptor binding transmembrane receptor protein tyrosine kinase adaptor activity SH2 domain binding signal transducer activity phosphatidylinositol 3-kinase binding protein binding protein kinase C binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase activity phosphotyrosine residue binding insulin receptor binding Cellular component cytoplasm intracellular membrane-bounded organelle caveola insulin receptor complex nucleus cytosol plasma membrane Biological process positive regulation of fatty acid beta-oxidation positive regulation of glucose import insulin-like growth factor receptor signaling pathway negative regulation of insulin secretion positive regulation of glycogen biosynthetic process glucose homeostasis response to peptide hormone positive regulation of glucose metabolic process MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity response to insulin negative regulation of insulin receptor signaling pathway positive regulation of cell population proliferation cellular response to insulin stimulus phosphatidylinositol 3-kinase signaling positive regulation of insulin receptor signaling pathway phosphatidylinositol-mediated signaling signal transduction insulin receptor signaling pathway phosphatidylinositol phosphate biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process interleukin-7-mediated signaling pathway positive regulation of protein kinase B signaling cellular response to fatty acid Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3667 16367 Ensembl ENSG00000169047 ENSMUSG00000055980 UniProt P35568 P35569 RefSeq (mRNA) NM_005544 NM_010570 RefSeq (protein) NP_005535 NP_034700 Location (UCSC) Chr 2: 226.73 – 226.8 Mb Chr 1: 82.21 – 82.27 Mb PubMed search [3] [4]
Wikidata
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Insulin receptor substrate 1 (IRS-1) is a signaling adapter protein that in humans is encoded by the IRS1 gene.^[5] It is a 180 kDa protein with amino acid sequence of 1242 residues.^[6] It contains a single pleckstrin homology (PH) domain at the N-terminus and a PTB domain ca. 40 residues downstream of this, followed by a poorly conserved C-terminus tail.^[7] Together with IRS2, IRS3 (pseudogene) and IRS4, it is homologous to the Drosophila protein chico, whose disruption extends the median lifespan of flies up to 48%.^[8] Similarly, Irs1 mutant mice experience moderate life extension and delayed age-related pathologies.^[9]