Integrasone

Integrasone
Names
Preferred IUPAC name
(1aR,2R,5R,6R,6aS)-6-Hexyl-2,6-dihydroxy-2,5,6,6a-tetrahydrooxireno[2,3-f] [2]benzofuran-3(1aH)-one
Other names
(+)-Integrasone
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
  • InChI=1S/C14H20O5/c1-2-3-4-5-6-7-8-9(14(17)18-7)11(16)13-12(19-13)10(8)15/h7,10-13,15-16H,2-6H2,1H3/t7-,10-,11-,12+,13-/m1/s1 ☒N
    Key: OHAVJEXAZZCXML-KDRYVUTISA-N ☒N
  • InChI=1/C14H20O5/c1-2-3-4-5-6-7-8-9(14(17)18-7)11(16)13-12(19-13)10(8)15/h7,10-13,15-16H,2-6H2,1H3/t7-,10-,11-,12+,13-/m1/s1
    Key: OHAVJEXAZZCXML-KDRYVUTIBW
  • O=C1O[C@H](CCCCCC)C2=C1[C@@H](O)[C@@H]3[C@@H](O3)[C@@H]2O
Properties
C14H20O5
Molar mass 268.309 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Integrasone is a polyketide natural product, isolated from an unknown fungus, that has been shown to inhibit the HIV-1 integrase enzyme.[1]

  1. ^ Herath, K.; Jayasuriya, H.; Bills, G.; Polishook, J.; Dombrowski, A.; Guan, Z.; Felock, P.; Hazuda, D.; Singh, S. Isolation, Structure, Absolute Stereochemistry and HIV-1 Inhibitory Activity of Integrasone, a Novel Fungal Polyketide. J. Nat. Prod. 2004, 67, 872-874.