Integrin alpha 4

ITGA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HKC, 3V4P, 3V4V, 5FPI, 5C7Z
Identifiers
Aliases	ITGA4, CD49D, IA4, integrin subunit alpha 4
External IDs	OMIM: 192975; MGI: 96603; HomoloGene: 37364; GeneCards: ITGA4; OMA:ITGA4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	181,538,940 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	79,163,467 bp
RNA expression pattern
	Top expressed in
	monocyte; ; bone marrow cells; ; granulocyte; ; appendix; ; blood; ; lymph node; ; spleen; ; trabecular bone; ; secondary oocyte; ; epithelium of colon;
	Top expressed in
	blood; ; spleen; ; lumbar spinal ganglion; ; mesenteric lymph nodes; ; internal carotid artery; ; external carotid artery; ; muscle layer of urethra; ; thymus; ; granulocyte; ; human fetus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein antigen binding; metal ion binding; antigen binding; fibronectin binding; cell adhesion molecule binding; coreceptor activity; C-X3-C chemokine binding; protein heterodimerization activity;
Cellular component	extracellular exosome; integral component of membrane; membrane; focal adhesion; cell surface; integrin alpha4-beta7 complex; integrin complex; plasma membrane; growth cone; soma; protein-containing complex;
Biological process	endodermal cell differentiation; B cell differentiation; positive regulation of T cell migration; extracellular matrix organization; heterotypic cell-cell adhesion; substrate adhesion-dependent cell spreading; cellular response to cytokine stimulus; cell-matrix adhesion involved in ameboidal cell migration; cell-matrix adhesion; leukocyte tethering or rolling; diapedesis; regulation of immune response; integrin-mediated signaling pathway; leukocyte migration; positive regulation of leukocyte tethering or rolling; positive regulation of leukocyte cell-cell adhesion; positive regulation of leukocyte migration; import into cell; leukocyte cell-cell adhesion; negative regulation of protein homodimerization activity; clathrin-dependent extracellular exosome endocytosis; cell adhesion; receptor clustering; cell-cell adhesion mediated by integrin; axonogenesis involved in innervation; cell-cell adhesion in response to extracellular stimulus; cellular response to amyloid-beta; positive regulation of vascular endothelial cell proliferation; neuron projection extension; positive regulation of endothelial cell apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	3676
	16401
	ENSG00000115232
	ENSMUSG00000027009
	P13612
	Q00651
	NM_000885; NM_001316312
	NM_010576
	NP_000876; NP_001303241
	NP_034706
	Wikidata
View/Edit Human	View/Edit Mouse

CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115232 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027009 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115232 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027009 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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