Integrin alpha 7

ITGA7
Identifiers
AliasesITGA7, integrin subunit alpha 7
External IDsOMIM: 600536; MGI: 102700; HomoloGene: 37592; GeneCards: ITGA7; OMA:ITGA7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008398
NM_001330160

RefSeq (protein)

n/a

Location (UCSC)Chr 12: 55.68 – 55.72 MbChr 10: 128.77 – 128.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene.[5][6] Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7 integrin is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. Mutations in ITGA7 have been associated with congenital myopathies and noncompaction cardiomyopathy, and altered expression levels of alpha-7 integrin have been identified in various forms of muscular dystrophy.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135424Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025348Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang W, Wu W, Desai T, Ward DC, Kaufman SJ (Aug 1995). "Localization of the alpha 7 integrin gene (ITGA7) on human chromosome 12q13: clustering of integrin and Hox genes implies parallel evolution of these gene families". Genomics. 26 (3): 568–70. doi:10.1016/0888-7543(95)80176-M. PMID 7607681.
  6. ^ "Entrez Gene: ITGA7 integrin, alpha 7".