Integrin alpha 8

ITGA8
Identifiers
Aliases	ITGA8, integrin subunit alpha 8
External IDs	OMIM: 604063; MGI: 109442; HomoloGene: 37396; GeneCards: ITGA8; OMA:ITGA8 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	15,719,922 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	12,306,733 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; urethra; ; right coronary artery; ; saphenous vein; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; left coronary artery; ; vena cava;
	Top expressed in
	ascending aorta; ; aortic valve; ; carotid body; ; right lung lobe; ; vas deferens; ; tunica media of zone of aorta; ; left lung lobe; ; vestibular membrane of cochlear duct; ; efferent ductule; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding;
Cellular component	integral component of membrane; perikaryon; membrane; postsynaptic density; focal adhesion; integrin alpha8-beta1 complex; plasma membrane; apical part of cell; cell surface; integrin complex; endoplasmic reticulum; dendritic spine membrane;
Biological process	positive regulation of transforming growth factor beta receptor signaling pathway; cell differentiation; kidney development; establishment of protein localization; extracellular matrix organization; memory; nervous system development; multicellular organism development; brain development; cell adhesion; cell projection organization; inner ear morphogenesis; positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; smooth muscle tissue development; mesodermal cell differentiation; integrin-mediated signaling pathway; substrate adhesion-dependent cell spreading; cell-matrix adhesion; metanephros development; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	8516
	241226
	ENSG00000077943
	ENSMUSG00000026768
	P53708
	A2ARA8
	NM_001291494; NM_003638
	NM_001001309
	NP_001278423; NP_003629
	NP_001001309; NP_001395029; NP_001395030; NP_001395031
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026768 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R (Jul 1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells". J Cell Sci. 108 (2): 537–44. doi:10.1242/jcs.108.2.537. PMID 7768999.
^ "Entrez Gene: ITGA8 integrin, alpha 8".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026768 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7768999-5] Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R (Jul 1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells". J Cell Sci. 108 (2): 537–44. doi:10.1242/jcs.108.2.537. PMID 7768999.

[entrez-6] "Entrez Gene: ITGA8 integrin, alpha 8".

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