Integrin beta 3

ITGB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4O02, 1JV2, 1KUP, 1KUZ, 1L5G, 1M1X, 1M8O, 1MIZ, 1MK7, 1MK9, 1S4X, 1TYE, 1U8C, 2K9J, 2KNC, 2KV9, 2L1C, 2L91, 2LJD, 2LJE, 2LJF, 2MTP, 2Q6W, 2RMZ, 2RN0, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3IJE, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 5HDB, 4Z7Q, 4Z7O, 4Z7N
Identifiers
Aliases	ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2
External IDs	OMIM: 173470; MGI: 96612; HomoloGene: 55444; GeneCards: ITGB3; OMA:ITGB3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	47,313,743 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	104,561,302 bp
RNA expression pattern
	Top expressed in
	monocyte; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; tendon of biceps brachii; ; popliteal artery; ; tibial arteries; ; right coronary artery;
	Top expressed in
	ascending aorta; ; aortic valve; ; decidua; ; blood; ; endothelial cell of lymphatic vessel; ; granulocyte; ; superior surface of tongue; ; femur; ; body of femur; ; zygote;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	vascular endothelial growth factor receptor 2 binding; fibronectin binding; virus receptor activity; extracellular matrix binding; protein disulfide isomerase activity; protease binding; platelet-derived growth factor receptor binding; protein binding; identical protein binding; enzyme binding; cell adhesion molecule binding; neuregulin binding; coreceptor activity; fibroblast growth factor binding; insulin-like growth factor I binding; C-X3-C chemokine binding; integrin binding; fibrinogen binding;
Cellular component	integral component of membrane; cell projection; alphav-beta3 integrin-vitronectin complex; membrane; focal adhesion; melanosome; receptor complex; plasma membrane; integral component of plasma membrane; ruffle membrane; cell surface; cell junction; integrin complex; platelet alpha granule membrane; integrin alphav-beta3 complex; extracellular exosome; lamellipodium membrane; nucleus; microvillus membrane; filopodium membrane; alphav-beta3 integrin-IGF-1-IGF1R complex; alphav-beta3 integrin-PKCalpha complex; alphav-beta3 integrin-HMGB1 complex; glutamatergic synapse; synapse;
Biological process	negative regulation of lipoprotein metabolic process; apolipoprotein A-I-mediated signaling pathway; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of protein phosphorylation; regulation of cell migration; negative chemotaxis; positive regulation of endothelial cell proliferation; tube development; heterotypic cell-cell adhesion; angiogenesis involved in wound healing; wound healing; platelet degranulation; blood coagulation; extracellular matrix organization; smooth muscle cell migration; positive regulation of endothelial cell migration; cell growth; cell-substrate adhesion; vascular endothelial growth factor receptor signaling pathway; cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; mesodermal cell differentiation; cell-substrate junction assembly; integrin-mediated signaling pathway; negative regulation of lipid storage; substrate adhesion-dependent cell spreading; negative regulation of lipid transport; cell-matrix adhesion; viral process; regulation of bone resorption; platelet aggregation; cell migration; negative regulation of macrophage derived foam cell differentiation; activation of protein kinase activity; leukocyte migration; cell adhesion mediated by integrin; platelet activation; apoptotic cell clearance; regulation of postsynaptic neurotransmitter receptor internalization; regulation of protein localization; regulation of serotonin uptake;
	Sources:Amigo / QuickGO
Orthologs
	3690
	16416
	ENSG00000259207
	ENSMUSG00000020689
	P05106
	O54890
	NM_000212
	NM_016780
	NP_000203
	NP_058060
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.^[5] CD61 is a cluster of differentiation found on thrombocytes.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000259207 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020689 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, et al. (June 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". The Journal of Clinical Investigation. 81 (6): 1993–1998. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.
^ Heemskerk JW, Mattheij NJ, Cosemans JM (January 2013). "Platelet-based coagulation: different populations, different functions". Journal of Thrombosis and Haemostasis. 11 (1): 2–16. doi:10.1111/jth.12045. PMID 23106920. S2CID 206157070.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000259207 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020689 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2454952-5] Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, et al. (June 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". The Journal of Clinical Investigation. 81 (6): 1993–1998. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.

[HeemskerkMattheij2013-6] Heemskerk JW, Mattheij NJ, Cosemans JM (January 2013). "Platelet-based coagulation: different populations, different functions". Journal of Thrombosis and Haemostasis. 11 (1): 2–16. doi:10.1111/jth.12045. PMID 23106920. S2CID 206157070.

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