Interferon Lambda 3

IFNL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HHC
Identifiers
Aliases	IFNL3, IL-28B, IL28B, IL28C, Interleukin 28B, interferon, lambda 3, interferon lambda 3, IFN-lambda-3, IFN-lambda-4, IL-28C
External IDs	OMIM: 607402; MGI: 2450574; HomoloGene: 77540; GeneCards: IFNL3; OMA:IFNL3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,245,250 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,223,747 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; superior frontal gyrus; ; prefrontal cortex; ; blood; ; skin of abdomen; ; placenta; ; temporal lobe; ; amygdala; ; urinary bladder;
	Top expressed in
	thymus; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; signaling receptor binding;
Cellular component	intracellular anatomical structure; extracellular space; extracellular region;
Biological process	receptor signaling pathway via JAK-STAT; negative regulation of viral genome replication; positive regulation of immune response; innate immune response; defense response to virus; regulation of T cell activation; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	282617
	338374
	ENSG00000197110
	ENSMUSG00000060747
	Q8IZI9
	Q8CGK6
	NM_172139; NM_001346937
	NM_177396
	NP_001333866; NP_742151
	NP_796370
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon lambda 3 (gene symbol: IFNL3) encodes the IFNL3 protein. IFNL3 was formerly named IL28B, but the Human Genome Organization Gene Nomenclature Committee renamed this gene in 2013 while assigning a name to the then newly discovered IFNL4 gene.^[5] Together with IFNL1 (formerly IL29) and IFNL2 (formerly IL28A), these genes lie in a cluster on chromosomal region 19q13. IFNL3 shares ~96% amino-acid identity with IFNL2, ~80% identity with IFNL1 and ~30% identity with IFNL4.

Interferon lambda genes encode cytokines classified as type III interferons, which are distantly related to type I interferons and the IL-10 family. Type III interferons are induced by viral infection and interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interferon lambda receptor 1 (IFNLR1) to signal via the JAK-STAT anti-viral pathway. [provided by RefSeq, Jul 2008].

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197110 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060747 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Prokunina-Olsson L, Muchmore B, Tang W, Pfeiffer RM, Park H, Dickensheets H, et al. (February 2013). "A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus". Nature Genetics. 45 (2): 164–71. doi:10.1038/ng.2521. PMC 3793390. PMID 23291588.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197110 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060747 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Prokunina-Olsson_2013-5] Prokunina-Olsson L, Muchmore B, Tang W, Pfeiffer RM, Park H, Dickensheets H, et al. (February 2013). "A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus". Nature Genetics. 45 (2): 164–71. doi:10.1038/ng.2521. PMC 3793390. PMID 23291588.

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