Interferon Lambda 4

IFNL4
Identifiers
Aliases	IFNL4, IFNAN, interferon, lambda 4 (gene/pseudogene), interferon lambda 4 (gene/pseudogene)
External IDs	OMIM: 615090; GeneCards: IFNL4; OMA:IFNL4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 39,246,314 bp[1] End 39,248,856 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad prefrontal cortex superior frontal gyrus hypothalamus substantia nigra anterior cingulate cortex temporal lobe amygdala hippocampus proper n/a More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity signaling receptor binding Cellular component cytoplasm extracellular region extracellular space Biological process innate immune response positive regulation of immune response regulation of T cell activation receptor signaling pathway via JAK-STAT defense response to virus tyrosine phosphorylation of STAT protein regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 101180976 n/a Ensembl ENSG00000272395 n/a UniProt K9M1U5 n/a RefSeq (mRNA) NM_001276254 n/a RefSeq (protein) NP_001263183 n/a Location (UCSC) Chr 19: 39.25 – 39.25 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Interferon lambda 4 (gene symbol: IFNL4) is one of the most recently discovered human genes and the newest addition to the interferon lambda protein family. This gene encodes the IFNL4 protein, which is involved in immune response to viral infection.

IFNL4 is similar to three neighboring genes (IFNL1, IFNL2 and IFNL3) in that proteins encoded by these genes bind to a shared co-receptor complex. Formation of this complex leads to activation of the JAK-STAT signalling pathway and upregulation of numerous interferon-stimulated genes. Genetics variants within or near this gene have been linked to clearance of hepatitis C virus (HCV) infection and other phenotypes.