Interleukin-17 receptor

Interleukin-17 receptor
Identifiers
SymbolIL17R
PfamPF08357
InterProIPR013568
Membranome8
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
interleukin 17 receptor A
Crystal structure of a complex of IL-17RA bound to IL-17F in a 1:2 stoichiometry.[1]
Identifiers
SymbolIL17RA
Alt. symbolsIL17R, CDw217
NCBI gene23765
HGNC5985
OMIM605461
RefSeqNM_014339
UniProtQ96F46
Other data
LocusChr. 22 q11.1
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StructuresSwiss-model
DomainsInterPro
interleukin 17 receptor B
Identifiers
SymbolIL17RB
Alt. symbolsIL17BR
NCBI gene55540
HGNC18015
OMIM605458
RefSeqNM_172234
UniProtQ9NRM6
Other data
LocusChr. 3 p21.1
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DomainsInterPro
interleukin 17 receptor C
Identifiers
SymbolIL17RC
Alt. symbolsIL17-RL
NCBI gene84818
HGNC18358
OMIM610925
RefSeqNM_032732
UniProtQ8NAC3
Other data
LocusChr. 3 p25.3
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StructuresSwiss-model
DomainsInterPro
Interleukin 17 receptor D
Identifiers
SymbolIL17RD
Alt. symbolsSEF, IL17RLM, FLJ35755, IL-17RD
NCBI gene54756
HGNC17616
OMIM606807
RefSeqNM_017563
UniProtQ8NFM7
Other data
LocusChr. 3 p21.1
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DomainsInterPro
interleukin 17 receptor E
Identifiers
SymbolIL17RE
Alt. symbolsFLJ23658
NCBI gene132014
HGNC18439
RefSeqNM_153480
UniProtQ8NFR9
Other data
LocusChr. 3 p25.3
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DomainsInterPro
Interleukin 17 receptor E-like
Identifiers
SymbolIL17REL
NCBI gene400935
HGNC33808
RefSeqNM_001001694
UniProtQ6ZVW7
Other data
LocusChr. 22 q13.33
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DomainsInterPro

Interleukin-17 receptor (IL-17R) is a cytokine receptor which belongs to new subfamily of receptors binding proinflammatory cytokine interleukin 17A, a member of IL-17 family ligands produced by T helper 17 cells (Th17).[2] IL-17R family consists of 5 members: IL-17RA, IL-17RB, IL-17RC, IL-17RD and IL-17RE. Functional IL-17R is a transmembrane receptor complex usually consisting of one IL-17RA, which is a founding member of the family, and second other family subunit, thus forming heteromeric receptor binding different ligands. IL-17A, a founding member of IL-17 ligand family binds to heteromeric IL-17RA/RC receptor complex.[3] IL-17RB binds preferentially IL-17B and IL-17E[4][5] and heteromeric IL-17RA/RE complex binds IL-17C. However, there is still unknown ligand for IL-17RD. The first identified member IL-17RA is located on human chromosome 22, whereas other subunits IL-17RB to IL-17RD are encoded within human chromosome 3.

  1. ^ PDB: 3JVF​; Ely LK, Fischer S, Garcia KC (December 2009). "Structural basis of receptor sharing by interleukin 17 cytokines". Nature Immunology. 10 (12): 1245–51. doi:10.1038/ni.1813. PMC 2783927. PMID 19838198.
  2. ^ Yao Z, Spriggs MK, Derry JM, Strockbine L, Park LS, VandenBos T, et al. (November 1997). "Molecular characterization of the human interleukin (IL)-17 receptor". Cytokine. 9 (11): 794–800. doi:10.1006/cyto.1997.0240. PMID 9367539.
  3. ^ Toy D, Kugler D, Wolfson M, Vanden Bos T, Gurgel J, Derry J, et al. (July 2006). "Cutting edge: interleukin 17 signals through a heteromeric receptor complex". Journal of Immunology. 177 (1): 36–9. doi:10.4049/jimmunol.177.1.36. PMID 16785495.
  4. ^ Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, et al. (June 2000). "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity". The Journal of Biological Chemistry. 275 (25): 19167–76. doi:10.1074/jbc.M910228199. PMID 10749887.
  5. ^ Lee J, Ho WH, Maruoka M, Corpuz RT, Baldwin DT, Foster JS, et al. (January 2001). "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1". The Journal of Biological Chemistry. 276 (2): 1660–4. doi:10.1074/jbc.M008289200. PMID 11058597.