Interleukin-4 receptor

IL4R
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL4R, CD124, IL-4RA, IL4RA, Interleukin-4 receptor, interleukin 4 receptor
External IDsOMIM: 147781; MGI: 105367; HomoloGene: 7784; GeneCards: IL4R; OMA:IL4R - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000418
NM_001008699
NM_001257406
NM_001257407
NM_001257997

NM_001008700
NM_001363983

RefSeq (protein)

NP_000409
NP_001244335
NP_001244336
NP_001244926

NP_001008700
NP_001350912

Location (UCSC)Chr 16: 27.31 – 27.36 MbChr 7: 125.15 – 125.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Interleukin-4 receptor alpha chain, N-terminal
interleukin-4 / receptor alpha chain complex
Identifiers
SymbolIL4Ra_N
PfamPF09238
InterProIPR015319
SCOP21iar / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The interleukin 4 receptor is a type I cytokine receptor. It is a heterodimer, that is, composed of two subunits. IL4R is the human gene coding for IL-4Rα, the subunit which combines with either common gamma chain (γc, forming the type I IL4 receptor) or with IL-13Rα1 (forming the type II IL4 receptor).[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000077238Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030748Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McCormick SM, Heller NM (September 2015). "Commentary: IL-4 and IL-13 receptors and signaling". Cytokine. 75 (1): 38–50. doi:10.1016/j.cyto.2015.05.023. PMC 4546937. PMID 26187331.