Interleukin 12

Human Interleukin 12
Crystal structure of human IL-12 (red helices)
Identifiers
SymbolIL12, p70
PDB1F45
IL12A
Identifiers
SymbolIL12A
Alt. symbolsCLMF1, NKSF1, p35
NCBI gene3592
HGNC5969
OMIM161560
RefSeqNM_000882
UniProtP29459
Other data
LocusChr. 3 p12-q13.2
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StructuresSwiss-model
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interleukin 12B
Crystal structure of IL-12B
Identifiers
SymbolIL12B
Alt. symbolsCLMF2, NKSF2, p40
NCBI gene3593
HGNC5970
OMIM161561
PDB1F42
RefSeqNM_002187
UniProtP29460
Other data
LocusChr. 5 q31.1-33.1
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StructuresSwiss-model
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Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells,[1] macrophages, neutrophils, helper T cells and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and IL-35.[2] Despite sharing many structural features and molecular partners, they mediate surprisingly diverse functional effects.

  1. ^ Kaliński P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML (July 1997). "IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells". Journal of Immunology. 159 (1): 28–35. doi:10.4049/jimmunol.159.1.28. PMID 9200435. S2CID 10617490.
  2. ^ Vignali DA, Kuchroo VK (July 2012). "IL-12 family cytokines: immunological playmakers". Nature Immunology. 13 (8): 722–8. doi:10.1038/ni.2366. PMC 4158817. PMID 22814351.