Interleukin 20 receptor, alpha subunit

IL20RA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DOH
Identifiers
Aliases	IL20RA, CRF2-8, IL-20R-alpha, IL-20R1, IL-20RA, Interleukin 20 receptor, alpha subunit, interleukin 20 receptor subunit alpha
External IDs	OMIM: 605620; MGI: 3605069; HomoloGene: 8685; GeneCards: IL20RA; OMA:IL20RA - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	137,045,180 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	19,635,801 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; skin of abdomen; ; right uterine tube; ; skin of leg; ; bronchial epithelial cell; ; testicle; ; endometrium; ; skin of thigh; ; palpebral conjunctiva; ; skin of arm;
	Top expressed in
	embryo; ; embryo; ; skin of external ear; ; lumbar subsegment of spinal cord; ; spermatid; ; lip; ; neural layer of retina; ; superior frontal gyrus; ; skin of abdomen; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; interleukin-20 binding; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	regulation of bone resorption; positive regulation of intrinsic apoptotic signaling pathway; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	53832
	237313
	ENSG00000016402
	ENSMUSG00000020007
	Q9UHF4
	Q6PHB0
	NM_001278722; NM_001278723; NM_001278724; NM_014432
	NM_172786
	NP_001265651; NP_001265652; NP_001265653; NP_055247
	NP_766374
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 20 receptor, alpha subunit, is a subunit of the interleukin-20 receptor, the interleukin-26 receptor, and the interleukin-24 receptor.^[5] The interleukin 20 receptor, alpha subunit is also referred to as IL20R1^[6] or IL20RA.^[7] The IL20RA receptor is involved in both pro-inflammatory and anti-inflammatory responses, signaling through the JAK-STAT pathway.^[5]

IL20RA is found in the skin, lungs, ovaries, testes and placenta, with low gene expression in the intestine and liver.^[7] IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RA is also found in some immune cells.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000016402 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020007 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Wegenka, Ursula Maria (2010-10-01). "IL-20: Biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews. IL-10 Family of Cytokines. 21 (5): 353–363. doi:10.1016/j.cytogfr.2010.08.001. ISSN 1359-6101. PMID 20864382.
^ Wirtz, Mary K.; Keller, Kate E. (2016). "The Role of the IL-20 Subfamily in Glaucoma". Mediators of Inflammation. 2016: 1–8. doi:10.1155/2016/4083735. ISSN 0962-9351. PMC 4745377. PMID 26903709.
^ ^a ^b Rutz, Sascha; Wang, Xiaoting; Ouyang, Wenjun (December 2014). "The IL-20 subfamily of cytokines — from host defence to tissue homeostasis". Nature Reviews Immunology. 14 (12): 783–795. doi:10.1038/nri3766. ISSN 1474-1741. PMID 25421700. S2CID 29114703.
^ Kragstrup, Tue W.; Andersen, Thomas; Heftdal, Line D.; Hvid, Malene; Gerwien, Jens; Sivakumar, Pallavur; Taylor, Peter C.; Senolt, Ladislav; Deleuran, Bent (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9: 2226. doi:10.3389/fimmu.2018.02226. ISSN 1664-3224. PMC 6167463. PMID 30319661.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000016402 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020007 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:03-5] Wegenka, Ursula Maria (2010-10-01). "IL-20: Biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews. IL-10 Family of Cytokines. 21 (5): 353–363. doi:10.1016/j.cytogfr.2010.08.001. ISSN 1359-6101. PMID 20864382.

[6] Wirtz, Mary K.; Keller, Kate E. (2016). "The Role of the IL-20 Subfamily in Glaucoma". Mediators of Inflammation. 2016: 1–8. doi:10.1155/2016/4083735. ISSN 0962-9351. PMC 4745377. PMID 26903709.

[:1-7] Rutz, Sascha; Wang, Xiaoting; Ouyang, Wenjun (December 2014). "The IL-20 subfamily of cytokines — from host defence to tissue homeostasis". Nature Reviews Immunology. 14 (12): 783–795. doi:10.1038/nri3766. ISSN 1474-1741. PMID 25421700. S2CID 29114703.

[:22-8] Kragstrup, Tue W.; Andersen, Thomas; Heftdal, Line D.; Hvid, Malene; Gerwien, Jens; Sivakumar, Pallavur; Taylor, Peter C.; Senolt, Ladislav; Deleuran, Bent (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9: 2226. doi:10.3389/fimmu.2018.02226. ISSN 1664-3224. PMC 6167463. PMID 30319661.

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