Interleukin 27

"IL-27" redirects here. For the road, see Illinois Route 27.

Interleukin 27 (IL-27) is a member of the IL-12 cytokine family. It is a heterodimeric cytokine that is encoded by two distinct genes, Epstein-Barr virus-induced gene 3 (EBI3) and IL-27p28. IL-27 is expressed by antigen presenting cells and interacts with a specific cell-surface receptor complex known as IL-27 receptor (IL-27R).[1][2][3][4][5] This receptor consists of two proteins, IL-27Rɑ and gp130. IL-27 induces differentiation of the diverse populations of T cells in the immune system and also upregulates IL-10.

  1. ^ Yoshida H, Hunter CA (April 2015). "The immunobiology of interleukin-27". Annual Review of Immunology. 33 (1): 417–43. doi:10.1146/annurev-immunol-032414-112134. PMID 25861977.
  2. ^ Meka RR, Venkatesha SH, Dudics S, Acharya B, Moudgil KD (December 2015). "IL-27-induced modulation of autoimmunity and its therapeutic potential". Autoimmunity Reviews. 14 (12): 1131–1141. doi:10.1016/j.autrev.2015.08.001. PMC 4628569. PMID 26253381.
  3. ^ Yoshimoto T, Chiba Y, Furusawa J, Xu M, Tsunoda R, Higuchi K, Mizoguchi I (September 2015). "Potential clinical application of interleukin-27 as an antitumor agent". Cancer Science. 106 (9): 1103–10. doi:10.1111/cas.12731. PMC 4582978. PMID 26132605.
  4. ^ Iwasaki Y, Fujio K, Okamura T, Yamamoto K (January 2015). "Interleukin-27 in T cell immunity". International Journal of Molecular Sciences. 16 (2): 2851–63. doi:10.3390/ijms16022851. PMC 4346869. PMID 25633106.
  5. ^ Aparicio-Siegmund S, Garbers C (October 2015). "The biology of interleukin-27 reveals unique pro- and anti-inflammatory functions in immunity". Cytokine & Growth Factor Reviews. 26 (5): 579–86. doi:10.1016/j.cytogfr.2015.07.008. PMID 26195434.